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Review

Ubiquitin Pathway and Ovarian Cancer

Department of Gynecology and Obstetrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2012, 19(6), 324-328; https://doi.org/10.3747/co.19.1175
Submission received: 6 September 2012 / Revised: 4 October 2012 / Accepted: 2 November 2012 / Published: 1 December 2012

Abstract

The ubiquitin–proteasome pathway is a common cellular process in eukaryotic tissue. Ubiquitin binds to proteins and tags them for destruction; this tagging directs proteins to the proteosome in the cell that degrades and recycles unneeded pro-teins. The ubiquitin–proteasome pathway plays an important role in the regulation of cellular proteins with respect to cell cycle control, transcription, apoptosis, cell adhesion, angiogenesis, and tumour growth. This review article discusses the various ways that the ubiquitin pathway is involved in ovarian cancer, such as modulating the ovarian-cancer-related gene BRCA1 and tumour suppres-sor p53, and interfering with the ERK pathway, the cyclin-dependent cell cycle regulation process, and ERBB2 gene expression.
Keywords: ubiquitin; protein degradation; ovarian cancer; gene expression; therapy ubiquitin; protein degradation; ovarian cancer; gene expression; therapy

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MDPI and ACS Style

Rao, Z.; Ding, Y. Ubiquitin Pathway and Ovarian Cancer. Curr. Oncol. 2012, 19, 324-328. https://doi.org/10.3747/co.19.1175

AMA Style

Rao Z, Ding Y. Ubiquitin Pathway and Ovarian Cancer. Current Oncology. 2012; 19(6):324-328. https://doi.org/10.3747/co.19.1175

Chicago/Turabian Style

Rao, Z., and Y. Ding. 2012. "Ubiquitin Pathway and Ovarian Cancer" Current Oncology 19, no. 6: 324-328. https://doi.org/10.3747/co.19.1175

APA Style

Rao, Z., & Ding, Y. (2012). Ubiquitin Pathway and Ovarian Cancer. Current Oncology, 19(6), 324-328. https://doi.org/10.3747/co.19.1175

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