Next Article in Journal
Prevalence and Risk Factors for Hepatitis B Virus Infection in Roma and Non-Roma People in Slovakia
Next Article in Special Issue
Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)
Previous Article in Journal
Nursing Intervention Practices for Smoking Cessation: A Large Survey in Hong Kong
Previous Article in Special Issue
Adult Premenopausal Bone Health Related to Reproductive Characteristics—Population-Based Data from the Canadian Multicentre Osteoporosis Study (CaMos)
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJERPH
Volume 15
Issue 5
10.3390/ijerph15051045
ijerph-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study

by
Diana Cabrera
1,2,*,
Marlena Kruger
1,3,
Frances M. Wolber
4,
Nicole C. Roy
2,3,5,
John J. Totman
6,
Christiani Jeyakumar Henry
7,
David Cameron-Smith
2,3,8 and
Karl Fraser
2,3,5
1
School of Food and Nutrition, Massey University, Tennent Drive, Palmerston North 4442, New Zealand
2
Food Nutrition & Health Team, Food & Bio-Based Products Group, AgResearch Grasslands, Palmerston North 4442, New Zealand
3
Riddet Institute, Massey University, Palmerston North 4442, New Zealand
4
Centre for Metabolic Health Research, Massey University, Tennent Drive, Palmerston North 4442, New Zealand
5
High-Value Nutrition National Science Challenge, Auckland 1142, New Zealand
6
A*Star-NUS Clinical Imaging Research Centre, Singapore 117599, Singapore
7
A*Star-NUS Clinical Nutrition Research Centre, Singapore 117599, Singapore
8
The Liggins Institute, The University of Auckland, Auckland 1142, New Zealand
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(5), 1045; https://doi.org/10.3390/ijerph15051045
Submission received: 12 March 2018 / Revised: 9 May 2018 / Accepted: 19 May 2018 / Published: 22 May 2018
(This article belongs to the Special Issue New Concepts in Women’s Bone Health)
Browse Figures
Versions Notes

Abstract

The diagnosis of osteoporosis is mainly based on clinical examination and bone mineral density assessments. The present pilot study compares the plasma lipid and polar metabolite profiles in blood plasma of 95 Singaporean-Chinese (SC) menopausal women with normal and low bone mineral density (BMD) using an untargeted metabolomic approach. The primary finding of this study was the association between lipids and femoral neck BMD in SC menopausal women. Twelve lipids were identified to be associated with low BMD by the orthogonal partial least squares (OPLS) model. Plasma concentrations of eight glycerophospholipid, glycerolipid, and sphingolipid species were significantly lower in menopausal women with low BMD but higher in two glycerophospholipid species (phosphatidylinositol and phosphatidic acid). Further, this study found no significant differences in plasma amino acid metabolites. However, trends for lower 4-aminobutyric acid, turanose, proline, aminopropionitrile, threonine, and methionine were found in women with low BMD. This pilot study identified associations between lipid metabolism and femoral neck BMD in SC women. Further studies are required on larger populations for evaluating the bone health effect of these compounds and their usefulness as clinical biomarkers for osteoporosis prediction in women.
Keywords: metabolomics; lipidomics; osteoporosis; menopause; biomarkers metabolomics; lipidomics; osteoporosis; menopause; biomarkers

Share and Cite

MDPI and ACS Style

Cabrera, D.; Kruger, M.; Wolber, F.M.; Roy, N.C.; Totman, J.J.; Henry, C.J.; Cameron-Smith, D.; Fraser, K. Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study. Int. J. Environ. Res. Public Health 2018, 15, 1045. https://doi.org/10.3390/ijerph15051045

AMA Style

Cabrera D, Kruger M, Wolber FM, Roy NC, Totman JJ, Henry CJ, Cameron-Smith D, Fraser K. Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study. International Journal of Environmental Research and Public Health. 2018; 15(5):1045. https://doi.org/10.3390/ijerph15051045

Chicago/Turabian Style

Cabrera, Diana, Marlena Kruger, Frances M. Wolber, Nicole C. Roy, John J. Totman, Christiani Jeyakumar Henry, David Cameron-Smith, and Karl Fraser. 2018. "Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study" International Journal of Environmental Research and Public Health 15, no. 5: 1045. https://doi.org/10.3390/ijerph15051045

APA Style

Cabrera, D., Kruger, M., Wolber, F. M., Roy, N. C., Totman, J. J., Henry, C. J., Cameron-Smith, D., & Fraser, K. (2018). Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study. International Journal of Environmental Research and Public Health, 15(5), 1045. https://doi.org/10.3390/ijerph15051045

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop