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Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study

1
School of Food and Nutrition, Massey University, Tennent Drive, Palmerston North 4442, New Zealand
2
Food Nutrition & Health Team, Food & Bio-Based Products Group, AgResearch Grasslands, Palmerston North 4442, New Zealand
3
Riddet Institute, Massey University, Palmerston North 4442, New Zealand
4
Centre for Metabolic Health Research, Massey University, Tennent Drive, Palmerston North 4442, New Zealand
5
High-Value Nutrition National Science Challenge, Auckland 1142, New Zealand
6
A*Star-NUS Clinical Imaging Research Centre, Singapore 117599, Singapore
7
A*Star-NUS Clinical Nutrition Research Centre, Singapore 117599, Singapore
8
The Liggins Institute, The University of Auckland, Auckland 1142, New Zealand
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(5), 1045; https://doi.org/10.3390/ijerph15051045
Received: 12 March 2018 / Revised: 9 May 2018 / Accepted: 19 May 2018 / Published: 22 May 2018
(This article belongs to the Special Issue New Concepts in Women’s Bone Health)
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Abstract

The diagnosis of osteoporosis is mainly based on clinical examination and bone mineral density assessments. The present pilot study compares the plasma lipid and polar metabolite profiles in blood plasma of 95 Singaporean-Chinese (SC) menopausal women with normal and low bone mineral density (BMD) using an untargeted metabolomic approach. The primary finding of this study was the association between lipids and femoral neck BMD in SC menopausal women. Twelve lipids were identified to be associated with low BMD by the orthogonal partial least squares (OPLS) model. Plasma concentrations of eight glycerophospholipid, glycerolipid, and sphingolipid species were significantly lower in menopausal women with low BMD but higher in two glycerophospholipid species (phosphatidylinositol and phosphatidic acid). Further, this study found no significant differences in plasma amino acid metabolites. However, trends for lower 4-aminobutyric acid, turanose, proline, aminopropionitrile, threonine, and methionine were found in women with low BMD. This pilot study identified associations between lipid metabolism and femoral neck BMD in SC women. Further studies are required on larger populations for evaluating the bone health effect of these compounds and their usefulness as clinical biomarkers for osteoporosis prediction in women. View Full-Text
Keywords: metabolomics; lipidomics; osteoporosis; menopause; biomarkers metabolomics; lipidomics; osteoporosis; menopause; biomarkers
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Cabrera, D.; Kruger, M.; Wolber, F.M.; Roy, N.C.; Totman, J.J.; Henry, C.J.; Cameron-Smith, D.; Fraser, K. Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study. Int. J. Environ. Res. Public Health 2018, 15, 1045.

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