Preventive Effect of Residential Green Space on Infantile Atopic Dermatitis Associated with Prenatal Air Pollution Exposure
by
Ji-Young Lee 1,
Dirga Kumar Lamichhane 2,
Myeongjee Lee 1,
Shinhee Ye 1,
Jung-Hyun Kwon 3,
Myung-Sook Park 4
,
Hwan-Cheol Kim 2,
Jong-Han Leem 2,
Yun-Chul Hong 5,
Yangho Kim 6,
Mina Ha 7 and
Eunhee Ha 1,*
Ji-Young Lee 1,
Dirga Kumar Lamichhane 2,
Myeongjee Lee 1,
Shinhee Ye 1,
Jung-Hyun Kwon 3,
Myung-Sook Park 4,
Hwan-Cheol Kim 2,
Jong-Han Leem 2,
Yun-Chul Hong 5,
Yangho Kim 6,
Mina Ha 7 and
Eunhee Ha 1,*
1
Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, Seoul 03760, Korea
2
Department of Occupational and Environmental Medicine, School of Medicine, Inha University, Incheon 22212, Korea
3
Department of Pediatrics, College of Medicine, Korea University, Seoul 02841, Korea
4
Taean Environmental Health Center, Taean 32144, Korea
5
Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 02841, Korea
6
Department of Occupational and Environmental Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan 44033, Korea
7
Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan 31116, Korea
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(1), 102; https://doi.org/10.3390/ijerph15010102
Received: 3 December 2017 / Revised: 28 December 2017 / Accepted: 3 January 2018 / Published: 9 January 2018
(This article belongs to the Special Issue Maternal and Child Health 2018)
Few birth cohort studies have examined the role of traffic-related air pollution (TRAP) in the development of infantile atopic dermatitis (AD), but none have investigated the role of preventive factors such as green spaces. The aim of this study was to investigate whether exposure to nitrogen dioxide (NO2) and particulate matter with an aerodynamic diameter of <10 μm (PM10) during pregnancy is associated with increased risk of development of AD in 6-month-old children and also to examine how this association changes with residential green space. This study used prospective data from 659 participants of the Mothers and Children’s Environmental Health study. Subjects were geocoded to their residential addresses and matched with air pollution data modeled using land-use regression. Information on infantile AD was obtained by using a questionnaire administered to the parents or guardians of the children. The association between infantile AD and exposure to NO2 and PM10 was determined using logistic regression models. We assessed the effects of residential green spaces using stratified analyses and by entering product terms into the logistic regression models. The risk of infantile AD significantly increased with an increase in air pollution exposure during the first trimester of pregnancy. The adjusted odds ratio (OR) and 95% confidence interval (CI) were 1.219 (1.023–1.452) per 10 μg/m3 increase in PM10 and 1.353 (1.027–1.782) per 10 ppb increase in NO2. An increase in the green space within 200 m of residence was associated with a decreased risk of AD (OR = 0.996, 95% CI: 0.993–0.999). The stratified analysis of residential green space revealed stronger associations between infantile AD and PM10 and NO2 exposure during the first trimester in the areas in the lower tertiles of green space. This study indicated that exposure to TRAP during the first trimester of pregnancy is associated with infantile AD. Less residential green space may intensify the association between TRAP exposure and infantile AD.
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Keywords:
child health; atopic dermatitis; greenness; traffic-related air pollution; particulate matter; birth cohort
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MDPI and ACS Style
Lee, J.-Y.; Lamichhane, D.K.; Lee, M.; Ye, S.; Kwon, J.-H.; Park, M.-S.; Kim, H.-C.; Leem, J.-H.; Hong, Y.-C.; Kim, Y.; Ha, M.; Ha, E. Preventive Effect of Residential Green Space on Infantile Atopic Dermatitis Associated with Prenatal Air Pollution Exposure. Int. J. Environ. Res. Public Health 2018, 15, 102.
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