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Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model

1
Molecular Epidemiology Branch, National Cancer Center, Goyang 410-769, Korea
2
Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan 330-714, Korea
3
Department of Food and Nutrition, College of Human Ecology, Kyung Hee University, Seoul 130-701, Korea
4
Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul 156-756, Korea
5
Department of Preventive Medicine and Heavy Metal Exposure Environmental Health Center, Dong-A University, Busan 602-714, Korea
6
Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 130-722, Korea
7
Advanced Analysis Center, Korea Institute of Science and Technology, Seoul 130-722, Korea
8
Department of Epidemiology and Biostatistics, School of Public health, Seoul National University, Seoul 151-742, Korea
9
Department of Preventive Medicine, College of Medicine, Chonnam National University, Gwangju 501-746, Korea
10
Department of Preventive Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea
11
Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 362-763, Korea
12
Department of Environmental Health, Korea National Open University, Seoul 110-791, Korea
13
Institute of Environmental Safety and Protection, NeoEnBiz Co., Bucheon 420-130, Korea
14
Food Safety Risk Assessment Division, National Institute of Food and Drug Safety Evaluation, Cheongwon 363-700, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2015, 12(8), 9054-9067; https://doi.org/10.3390/ijerph120809054
Received: 21 May 2015 / Revised: 15 July 2015 / Accepted: 28 July 2015 / Published: 31 July 2015
Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 ± 8.6 days. The population mean of the methylmercury half-life was 81.6 ± 8.4 days for men and 78.9 ± 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 ± 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values. View Full-Text
Keywords: biological half-life; dietary exposure; methylmercury; one-compartment toxicokinetic model; population model biological half-life; dietary exposure; methylmercury; one-compartment toxicokinetic model; population model
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Jo, S.; Woo, H.D.; Kwon, H.-J.; Oh, S.-Y.; Park, J.-D.; Hong, Y.-S.; Pyo, H.; Park, K.S.; Ha, M.; Kim, H.; Sohn, S.-J.; Kim, Y.-M.; Lim, J.-A.; Lee, S.-A.; Eom, S.-Y.; Kim, B.-G.; Lee, K.-M.; Lee, J.-H.; Hwang, M.S.; Kim, J. Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model. Int. J. Environ. Res. Public Health 2015, 12, 9054-9067.

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