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Open AccessCommunication

New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745

by 1,†, 2,†, 2,* and 1,*
1
Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China
2
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
*
Authors to whom correspondence should be addressed.
These authors contributed equal to this work.
Mar. Drugs 2018, 16(9), 330; https://doi.org/10.3390/md16090330
Received: 11 August 2018 / Revised: 30 August 2018 / Accepted: 10 September 2018 / Published: 12 September 2018
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F (1) and G (2) showed antibacterial activity against Escherichia coli, with MIC values of 41.8 and 61.7 μM, respectively. View Full-Text
Keywords: Streptomyces sp. ZZ745; bagremycin F; bagremycin G; antibacterial activity Streptomyces sp. ZZ745; bagremycin F; bagremycin G; antibacterial activity
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MDPI and ACS Style

Zhang, D.; Shu, C.; Lian, X.; Zhang, Z. New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745. Mar. Drugs 2018, 16, 330.

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