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Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Analytical and Testing Center, Beijing University of Chemical Technology, Beijing 100029, China
Author to whom correspondence should be addressed.
Mar. Drugs 2013, 11(5), 1524-1533;
Received: 16 February 2013 / Revised: 18 April 2013 / Accepted: 24 April 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Deep-Sea Natural Products)
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Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A–C (35), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn2+ complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae. View Full-Text
Keywords: deep-sea water; Streptomyces olivaceus; tetroazolemycin; siderophore deep-sea water; Streptomyces olivaceus; tetroazolemycin; siderophore

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Liu, N.; Shang, F.; Xi, L.; Huang, Y. Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012. Mar. Drugs 2013, 11, 1524-1533.

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