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Volume 61
Issue 9
10.3390/medicina61091544
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Impact of Adipokine Expression on Tumor Characteristics and Survival Outcomes in Patients with Renal Cell Carcinoma

by
Oktay Halit Aktepe
1,*,†,
Tugce Ulasli
1,†,
Aytac Terzi
1,
Fatma Gundogdu
2,
Eda Caliskan Yildirim
3,
Ahmet Melih Arslan
1,
Huseyin Salih Semiz
1,
Kemal Kosemehmetoglu
2,
Aziz Karaoglu
1,
Mustafa Erman
4 and
Suayib Yalcin
4
1
Department of Medical Oncology, Dokuz Eylul University, Izmir 35330, Turkey
2
Department of Pathology, Hacettepe University, Ankara 06230, Turkey
3
Department of Medical Oncology, Sincan Research and Training Hospital, Ankara 06949, Turkey
4
Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara 06230, Turkey;ermanm1968@gmail.com (M.E.)
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Medicina 2025, 61(9), 1544; https://doi.org/10.3390/medicina61091544
Submission received: 11 July 2025 / Revised: 6 August 2025 / Accepted: 25 August 2025 / Published: 27 August 2025
(This article belongs to the Section Oncology)
Versions Notes

Abstract

Background and Objectives: To investigate the clinical significance of adipokines’ [leptin, leptin receptor (leptin-R), adiponectin, and resistin] expression on the characteristics and survival outcomes of patients with renal cell carcinoma (RCC). Materials and Methods: A total of 81 patients were included. The expressions of adipokines in the nephrectomy material of the patients were assessed using immunohistochemistry. Staining patterns were divided into two groups for statistical analyses: negative (no staining) and positive. Univariable and multivariable Cox regression models were used to evaluate the impact of the expression of adipokines on the survival outcomes of the patients. Results: The percentages of patients expressing leptin, leptin-R, adiponectin, and resistin were 36.4%, 30.7%, 32%, and 60.2%, respectively. The median overall survival (OS) of all patients was 53.7 months (95% confidence interval [CI]: 39.9–67.5). In the multivariate analyses, only leptin expression status was associated with OS among adipokines (hazard ratio [HR]: 1.98, 95%CI: 1.03–3.78, p = 0.039) in addition to the presence of distant metastasis (HR: 2.48, 95%CI: 1.16–5.29, p = 0.018). No significant associations were determined between adipokine expression and pathologic determinants of RCC, including tumor stage, grade, and histological subtype. Conclusions: Our study demonstrated that leptin expression was an independent prognostic factor for inferior OS in RCC patients treated with nephrectomy, even after adjusting for disease stage in multivariate analysis.
Keywords: adipokine; adiponectin; leptin; renal cell carcinoma; resistin adipokine; adiponectin; leptin; renal cell carcinoma; resistin

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MDPI and ACS Style

Aktepe, O.H.; Ulasli, T.; Terzi, A.; Gundogdu, F.; Caliskan Yildirim, E.; Arslan, A.M.; Semiz, H.S.; Kosemehmetoglu, K.; Karaoglu, A.; Erman, M.; et al. Impact of Adipokine Expression on Tumor Characteristics and Survival Outcomes in Patients with Renal Cell Carcinoma. Medicina 2025, 61, 1544. https://doi.org/10.3390/medicina61091544

AMA Style

Aktepe OH, Ulasli T, Terzi A, Gundogdu F, Caliskan Yildirim E, Arslan AM, Semiz HS, Kosemehmetoglu K, Karaoglu A, Erman M, et al. Impact of Adipokine Expression on Tumor Characteristics and Survival Outcomes in Patients with Renal Cell Carcinoma. Medicina. 2025; 61(9):1544. https://doi.org/10.3390/medicina61091544

Chicago/Turabian Style

Aktepe, Oktay Halit, Tugce Ulasli, Aytac Terzi, Fatma Gundogdu, Eda Caliskan Yildirim, Ahmet Melih Arslan, Huseyin Salih Semiz, Kemal Kosemehmetoglu, Aziz Karaoglu, Mustafa Erman, and et al. 2025. "Impact of Adipokine Expression on Tumor Characteristics and Survival Outcomes in Patients with Renal Cell Carcinoma" Medicina 61, no. 9: 1544. https://doi.org/10.3390/medicina61091544

APA Style

Aktepe, O. H., Ulasli, T., Terzi, A., Gundogdu, F., Caliskan Yildirim, E., Arslan, A. M., Semiz, H. S., Kosemehmetoglu, K., Karaoglu, A., Erman, M., & Yalcin, S. (2025). Impact of Adipokine Expression on Tumor Characteristics and Survival Outcomes in Patients with Renal Cell Carcinoma. Medicina, 61(9), 1544. https://doi.org/10.3390/medicina61091544

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