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Article

Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study

by
Nicoleta Stefania Motoc
1,2,†,
Victoria-Maria Ruta
2,3,†,
Milena Adina Man
1,2,*,
Rodica Ana Ungur
4,
Viorela Mihaela Ciortea
4,
Laszlo Irsay
4,
Andrea Nicola
5,
Dan Valean
6,
Lia Oxana Usatiuc
3,
Ileana Rodica Matei
7 and
Ileana Monica Borda
4
1
Department of Medical Sciences-Pulmonology, Faculty of Medicine, University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
2
“Leon Daniello” Clinical Hospital of Pneumophtysiology, 400371 Cluj-Napoca, Romania
3
“Iuliu-Hațieganu” PhD Student, Doctoral School, University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
4
Department of Medical Specialties, Faculty of Medicine, ”Iuliu-Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
5
Department of Molecular Sciences, Faculty of Medicine, University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
6
Department of General Surgery, Fifth Medical Clinic, No 11 Tăbăcarilor Street, 400139 Cluj-Napoca, Romania
7
Plastic Surgery Department, Faculty of Medicine, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Medicina 2022, 58(6), 707; https://doi.org/10.3390/medicina58060707
Submission received: 25 April 2022 / Revised: 22 May 2022 / Accepted: 23 May 2022 / Published: 26 May 2022
(This article belongs to the Section Infectious Disease)
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Abstract

Background and objectives: This article aims to evaluate the number of days necessary for patients with mild and moderate forms of COVID-19 to reach undetectable levels of SARS-CoV-2 RNA in the upper respiratory tract specimens. As a secondary objective, we sought to establish a correlation between different conditions associated with longer viral load as this could result in a longer period of contagion and infectivity. Materials and Methods: It is a retrospective study. A total of 70 patients with confirmed mild and moderate forms of COVID-19 were enrolled in our study. Results: Number of days with traceable viral load was 25.93 (±6.02) days in patients with mild COVID-19 and 26.97 (±8.30) in moderate form (p = 0.72). Age, male gender, and obesity, along with several chronic conditions (cardiac, liver, renal, and neurological disease), were associated with prolonged positive RT-PCR test from the nasal swab (therefore prolonged viral load). These are in general, risk factors for severe forms of COVID-19. Conclusions: There are several conditions associated with prolonged positive RT-PCR in mild and moderate forms of COVID-19. As to why and what is the significance of it remains to be studied.
Keywords: COVID-19; prolonged viral load; viral clearance; risk factors COVID-19; prolonged viral load; viral clearance; risk factors

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MDPI and ACS Style

Motoc, N.S.; Ruta, V.-M.; Man, M.A.; Ungur, R.A.; Ciortea, V.M.; Irsay, L.; Nicola, A.; Valean, D.; Usatiuc, L.O.; Matei, I.R.; et al. Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study. Medicina 2022, 58, 707. https://doi.org/10.3390/medicina58060707

AMA Style

Motoc NS, Ruta V-M, Man MA, Ungur RA, Ciortea VM, Irsay L, Nicola A, Valean D, Usatiuc LO, Matei IR, et al. Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study. Medicina. 2022; 58(6):707. https://doi.org/10.3390/medicina58060707

Chicago/Turabian Style

Motoc, Nicoleta Stefania, Victoria-Maria Ruta, Milena Adina Man, Rodica Ana Ungur, Viorela Mihaela Ciortea, Laszlo Irsay, Andrea Nicola, Dan Valean, Lia Oxana Usatiuc, Ileana Rodica Matei, and et al. 2022. "Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study" Medicina 58, no. 6: 707. https://doi.org/10.3390/medicina58060707

APA Style

Motoc, N. S., Ruta, V.-M., Man, M. A., Ungur, R. A., Ciortea, V. M., Irsay, L., Nicola, A., Valean, D., Usatiuc, L. O., Matei, I. R., & Borda, I. M. (2022). Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study. Medicina, 58(6), 707. https://doi.org/10.3390/medicina58060707

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