Abstract
Background: Sports practice, particularly eccentric exercises, induces significant muscular changes, including muscle fiber injuries, strength loss, pain, and increased permeability of the muscle membrane. The duration of muscle recovery depends on factors such as exercise intensity and the specific muscle groups engaged. The inflammatory response plays a crucial role in muscle regeneration, involving various cell types. Curcumin, especially when its stability is enhanced through encapsulation, exhibits potent antioxidant and anti-inflammatory properties. Supplementing with curcumin can reduce muscle damage and inflammation caused by eccentric exercise, making it a potential remedy for athletes. Objective: The objective of this systematic review is to assess the scientific evidence supporting the efficacy of curcumin in reducing muscle damage caused by sports. Methods: A structured search in SCOPUS, Medline, and Web of Science databases was conducted in March 2023, including all available articles. The strategy involved selecting English articles without time constraints, using the search terms “curcumin” AND “Exercise- Induced Muscle Damage” (ALL(curcumin AND “Exercise-Induced Muscle Damage”)). Titles and abstracts were screened to assess eligibility. Studies were chosen based on PICOS criteria, and quality was evaluated using the reliable PEDro scale. The eligibility criteria included adults without any diagnosed diseases who regularly exercise (at least three times per week) and follow a consistent pattern of curcumin intake before, during, or after exercise. Results: The comprehensive search identified 11 relevant studies investigating the effects of curcumin supplementation in sportsimulated interventions. These studies suggest that curcumin intake may help reduce muscle symptoms associated with eccentric exercises, thereby improving pain perception. Effective use of curcumin depends on factors such as dosage, bioavailability, and timing, with post-exercise ingestion appearing to be more beneficial. Conclusions: Curcumin demonstrates a significant potential to relieve muscle-related symptoms, especially delayed-onset muscle soreness (DOMS) that arises from eccentric exercises, thus potentially improving the well-being of those who are trained. It also appears to have the capability to lower biomarkers associated with inflammation and boost antioxidant levels. Nevertheless, for future studies, the bioavailability of curcumin must be considered, as it is a key factor in its efficacy.