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Volume 40
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10.21775/cimb.040.221
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

OASs in Defense of Mycobacterial Infection: Angels or Demons?

by
Weipan Zhang
,
Xiaojian Cao
,
Gang Cao
and
Xi Chen
*
State Key laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2021, 40(1), 221-230; https://doi.org/10.21775/cimb.040.221
Submission received: 8 April 2020 / Revised: 11 May 2020 / Accepted: 12 June 2020 / Published: 1 July 2020
Versions Notes

Abstract

The interaction between pattern-recognition receptors (PRRs) and pathogen- associated molecular patterns (PAMPs) induces type I interferon (IFN) responses. IFNs stimulates hundreds of genes to exert its biological effects. OASs are the members of IFN-stimulate genes (ISGs). Among them, OAS1 activates RNase L to cleave RNA viruses genome, OAS2 activates downstream immune signaling pathways of IFNs, OAS3 induces RNase L to cut the genome of RNA virus and activate IFN I response to enhance the immune effect, and OASL inhibits the survival of RNA viruses by activating RIG-I signaling pathway but promotes the reproduction of DNA viruses by inhibiting the cGAS signaling pathway. However, the role of OASs in mycobacterial infection remains incomprehensible. In this review, we summarized the latest literature regarding the roles of OASs in mycobacterial infection.
Keywords: defense; mycobacterial; infection:; angels; demons defense; mycobacterial; infection:; angels; demons

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MDPI and ACS Style

Zhang, W.; Cao, X.; Cao, G.; Chen, X. OASs in Defense of Mycobacterial Infection: Angels or Demons? Curr. Issues Mol. Biol. 2021, 40, 221-230. https://doi.org/10.21775/cimb.040.221

AMA Style

Zhang W, Cao X, Cao G, Chen X. OASs in Defense of Mycobacterial Infection: Angels or Demons? Current Issues in Molecular Biology. 2021; 40(1):221-230. https://doi.org/10.21775/cimb.040.221

Chicago/Turabian Style

Zhang, Weipan, Xiaojian Cao, Gang Cao, and Xi Chen. 2021. "OASs in Defense of Mycobacterial Infection: Angels or Demons?" Current Issues in Molecular Biology 40, no. 1: 221-230. https://doi.org/10.21775/cimb.040.221

APA Style

Zhang, W., Cao, X., Cao, G., & Chen, X. (2021). OASs in Defense of Mycobacterial Infection: Angels or Demons? Current Issues in Molecular Biology, 40(1), 221-230. https://doi.org/10.21775/cimb.040.221

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