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Volume 13
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10.21775/cimb.013.025
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Review

Role of Fusobacterium nucleatum in Periodontal Health and Disease

by
Benoit Signat
1,*,
Christine Roques
2,
Pierre Poulet
1 and
Danielle Duffaut
1
1
Department of Oral Biology, Faculty of Dental Surgery, University Paul Sabatier, Toulouse, France
2
Industrial Microbiology Pharmacology, Faculty of Pharmaceutical Sciences, University Paul Sabatier, Toulouse, France
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2011, 13(2), 25-36; https://doi.org/10.21775/cimb.013.025
Submission received: 6 July 2010 / Revised: 7 September 2010 / Accepted: 9 November 2010 / Published: 10 January 2011

Abstract

The pathogenesis of periodontitis involves the interplay of microbiota present in the subgingival plaque and the host responses. Inflammation and destruction of periodontal tissues are considered to result from the response of a susceptible host to a microbial biofilm containing gram-negative pathogens. Antimicrobial peptides are important contributors to maintaining the balance between health and disease in this complex environment. These include several salivary antimicrobial peptides such as beta-defensins expressed in the epithelium and LL-37 expressed in both epithelium and neutrophils. Among gram-negative bacteria implicated in periodontal diseases, Fusobacterium nucleatum, is one of the most interesting. This review will focus on expression, function, regulation and functional efficacy of antimicrobial peptides against F. nucleatum. We are looking for how the presence of F. nucleatum induces secretion of peptides which have an impact on host cells and modulate immune response.
Keywords: antimicrobial peptides; subgingival plaque; salivary antimicrobial peptides; beta-defensins; LL-37; periodontal diseases; Fusobacterium nucleatum; F. nucleatum antimicrobial peptides; subgingival plaque; salivary antimicrobial peptides; beta-defensins; LL-37; periodontal diseases; Fusobacterium nucleatum; F. nucleatum

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MDPI and ACS Style

Signat, B.; Roques, C.; Poulet, P.; Duffaut, D. Role of Fusobacterium nucleatum in Periodontal Health and Disease. Curr. Issues Mol. Biol. 2011, 13, 25-36. https://doi.org/10.21775/cimb.013.025

AMA Style

Signat B, Roques C, Poulet P, Duffaut D. Role of Fusobacterium nucleatum in Periodontal Health and Disease. Current Issues in Molecular Biology. 2011; 13(2):25-36. https://doi.org/10.21775/cimb.013.025

Chicago/Turabian Style

Signat, Benoit, Christine Roques, Pierre Poulet, and Danielle Duffaut. 2011. "Role of Fusobacterium nucleatum in Periodontal Health and Disease" Current Issues in Molecular Biology 13, no. 2: 25-36. https://doi.org/10.21775/cimb.013.025

APA Style

Signat, B., Roques, C., Poulet, P., & Duffaut, D. (2011). Role of Fusobacterium nucleatum in Periodontal Health and Disease. Current Issues in Molecular Biology, 13(2), 25-36. https://doi.org/10.21775/cimb.013.025

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