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Sensors 2007, 7(11), 2808-2824;

Antimicrobial Peptides: New Recognition Molecules for Detecting Botulinum Toxins

Center for Bio/Molecular Science & Engineering, Code 6900, Naval Research Laboratory, 4555 Overlook Ave. SW, Washington, DC 20375, USA
Author to whom correspondence should be addressed.
Received: 24 October 2007 / Accepted: 14 November 2007 / Published: 16 November 2007
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Many organisms secrete antimicrobial peptides (AMPs) for protection againstharmful microbes. The present study describes detection of botulinum neurotoxoids A, Band E using AMPs as recognition elements in an array biosensor. While AMP affinitieswere similar to those for anti-botulinum antibodies, differences in binding patterns wereobserved and can potentially be used for identification of toxoid serotype. Furthermore,some AMPs also demonstrated superior detection sensitivity compared to antibodies: toxoidA could be detected at 3.5 LD50 of the active toxin in a 75-min assay, whereas toxoids B andE were detected at 14 and 80 LD50 for their respective toxins. View Full-Text
Keywords: Antimicrobial peptide; botulinum toxin; detection; array; biosensor Antimicrobial peptide; botulinum toxin; detection; array; biosensor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kulagina, N.V.; Anderson, G.P.; Ligler, F.S.; Shaffer, K.M.; Taitt, C.R. Antimicrobial Peptides: New Recognition Molecules for Detecting Botulinum Toxins. Sensors 2007, 7, 2808-2824.

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