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Sensors, Volume 19, Issue 23 (December-1 2019)
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Cover Story (view full-size image) Nanoparticles are emerging materials with outstanding potential for their use as labels in [...] Read more. Nanoparticles are emerging materials with outstanding potential for their use as labels in electrochemical immunosensing. Gold, silver, palladium, and platinum are the main components of such particles, thanks to their direct electroactivity (redox properties) and/or their electrocatalytic activity towards secondary reactions. While the direct detection is faster and simpler, electrocatalytic strategies are generally more sensitive. The recent use of nanoparticles in combination with nanochannels for immunosensing approaches also deserves to be highlighted, being especially advantageous for real sample analysis thanks to the filtering abilities of the nanoporous-based platforms. Protein biomarkers of a variety of diseases, including tumor cells, are the target analytes on which such electrochemical immunosensors have been mostly applied.View this paper.