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Molbank
Volume 2026
Issue 2
10.3390/M2162
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Short Note

[2-{(5′-Amino-2′-fluoroacetophenone)-5-nitro}]acetophenone

by
Richard M. Beteck
* and
Lesetja J. Legoabe
Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa
*
Author to whom correspondence should be addressed.
Molbank 2026, 2026(2), M2162; https://doi.org/10.3390/M2162
Submission received: 2 February 2026 / Revised: 6 April 2026 / Accepted: 8 April 2026 / Published: 10 April 2026
(This article belongs to the Collection Molecules from Side Reactions)
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Abstract

Herein we reported on a one-pot nitro reduction/nucleophilic aromatic substitution on 1-(2-fluoro-5-nitrophenyl)ethan-1-one using a mixture of acetic acid and iron powder in ethanol. The resultant target compound, a nitrated N bis-acetophenone, has many reactive handles; as such, it is a novel intermediate that can be deployed for the syntheses of a vast array of compounds not reported before. This compound is fully characterized using 1H and 13C NMR spectroscopy, and HRMS.
Keywords: nitro compounds; acetophenone; nitro reduction; intermediate nitro compounds; acetophenone; nitro reduction; intermediate
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MDPI and ACS Style

Beteck, R.M.; Legoabe, L.J. [2-{(5′-Amino-2′-fluoroacetophenone)-5-nitro}]acetophenone. Molbank 2026, 2026, M2162. https://doi.org/10.3390/M2162

AMA Style

Beteck RM, Legoabe LJ. [2-{(5′-Amino-2′-fluoroacetophenone)-5-nitro}]acetophenone. Molbank. 2026; 2026(2):M2162. https://doi.org/10.3390/M2162

Chicago/Turabian Style

Beteck, Richard M., and Lesetja J. Legoabe. 2026. "[2-{(5′-Amino-2′-fluoroacetophenone)-5-nitro}]acetophenone" Molbank 2026, no. 2: M2162. https://doi.org/10.3390/M2162

APA Style

Beteck, R. M., & Legoabe, L. J. (2026). [2-{(5′-Amino-2′-fluoroacetophenone)-5-nitro}]acetophenone. Molbank, 2026(2), M2162. https://doi.org/10.3390/M2162

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