Review Reports

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

A review-type manuscript entitled ‘Lysophospholipid Signaling Molecules in Fundus Neovascular Diseases’ was submitted by C. Fu and coworkers to be considered for its publication in the Int. J. Mol. Sci. Thus, after having read carefully the manuscript, I consider it suitable for the chosen journal because it fits into its scope, meeting well its standards regarding aspects like novelty, originality and general interest on the topic for the wide readership of the journal. Indeed, I consider the paper publishable practically in its present form due to many positive reasons, among which it is worth highlighting the ease of being read because it is masterfully discussed but mainly the high importance of fundus neovascular diseases and related potential treatments. In addition, regarding the manuscript, the introduction shows suitably the context of the work. References cited are enough and pertinent. The paper is divided into logical sections and subsections. Conclusions and perspectives are supported by the current knowledge. My sole suggestions is to include catch-eye images (like those in section 2) to sections 1, 3 and 4.

Author Response

 Dear Editors,

We would like to thank you and the reviewers for the constructive comments and suggestions, which have been substantially beneficial to improving the quality of our manuscript. We have carefully revised the manuscript based on these comments.

In this letter, we reply with our point-to-point response in light of the reviewers’ concerns. All changes in the revised manuscript have been highlighted with yellow shading for your reference.

Yours sincerely,

Changzhen Fu

We sincerely thank the reviewer for this valuable suggestion, with which we fully agree, as it helps improve the paper’s readability and information delivery. Accordingly, we added Figure 1 in Section 1 to illustrate the core mechanism. To improve logical flow and integration, we condensed the key content of the original Sections 3 and 4 into the newly drawn Figure 4. The relevant revisions appear on pages 3 and 15 of the main text (Figures 1 and 4); the figure legends are highlighted in yellow.

Reviewer 2 Report

Comments and Suggestions for Authors This review by  Zhou   et al. examines the role of lysophospholipid mediators in the pathogenesis of neovascular diseases of the ocular fundus. This paper systematizes data on the metabolic pathways and signaling networks of lysophosphatidic acid, lysophosphatidylcholine, and sphingosine-1-phosphate, with the aim of establishing a rationale for new therapeutic approaches. Particular attention is paid to pro-angiogenic regulatory effects of lysophospholipid signaling molecules and the application of these effects in the treatment of neovascular diseases of the ocular fundus. As far as I am aware, reviews on this topic were published several years ago, but a great deal of new data has been accumulated since then, which the authors have sought to cover in this paper.   The paper is well structured; the 2 figures complement the text.  Abstract gives the necessary information about the contents of the paper, keywords are appropriately chosen. The reference list covers the relevant literature: the authors cite 145 references, about 70% of which were published within the last five years.    However, I have one technical remark: Please look into reference 106; it consists of Chinese characters - is there no English translation available for it?

Author Response

Dear Editors,

We would like to thank you and the reviewers for the constructive comments and suggestions, which have been substantially beneficial to improving the quality of our manuscript. We have carefully revised the manuscript based on these comments.

In this letter, we reply with our point-to-point response in light of the reviewers’ concerns. All changes in the revised manuscript have been highlighted with yellow shading for your reference.

Yours sincerely,

Changzhen Fu

We sincerely thank the reviewer for this careful review and valuable correction. This issue was indeed an oversight on our part and has now been corrected in the reference list (page 26, line 1084; highlighted in yellow).

specifically as:  “106. 赵燕颖, -., et al., - 溶血磷脂酸（LPA）对肝癌细胞的影响及相关机制的初步探讨. - 临床肝胆病杂志, 2023. - 39(- 11): p. - 2623. ” → “106. ZHAO, Y., et al., Effect of lysophosphatidic acid on hepatoma cells and related mechanism. -Journal of Clinical Hepatology, 2023. 39(11): p. 2623-2628.”.

Round 2

Reviewer 1 Report

Comments and Suggestions for Authors

The manuscript has been enhanced considerably. Thus, it sould be accepted for its publication in its present form!