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Article

Chronic Treatment with Nigella sativa Oil Exerts Antimanic Properties and Reduces Brain Inflammation in Rats

by
Sarit Uzzan
1,
Ira-Sivan Rostevanov
1,
Elina Rubin
1,
Olivia Benguigui
2,
Said Marazka
3,
Jacob Kaplanski
1,
Riad Agbaria
1,† and
Abed N. Azab
1,4,*,†
1
Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
2
Department of Kinesiology and Physical Education, McGill University, 475 Pine Avenue West, Montreal, QC H2W1S4, Canada
3
Department of Cognitive and Brain Sciences, Faculty of Humanities and Social Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
4
Department of Nursing, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(3), 1823; https://doi.org/10.3390/ijms25031823
Submission received: 21 December 2023 / Revised: 29 January 2024 / Accepted: 30 January 2024 / Published: 2 February 2024
(This article belongs to the Special Issue Modeling Neurological Disorders in Experimental Animals: New Insights and Emerging Roles 3.0)
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Abstract

Nigella sativa (NS) is a native herb consumed habitually in several countries worldwide, possessing manifold therapeutic properties. Among them, anti-inflammatory features have been reported, presumably relating to mechanisms involved in the nuclear factor kappa-B pathway, among others. Given the observed association between neuroimmune factors and mental illness, the primary aim of the present study was to examine the effects of chronic NS use on manic-like behavior in rats, as well as analyze levels of brain inflammatory mediators following NS intake. Using male and female rats, baseline tests were performed; thereafter, rats were fed either regular food (control) or NS-containing food (treatment) for four weeks. Following intervention, behavioral tests were induced (an open field test, sucrose consumption test, three-chamber sociality test, and amphetamine-induced hyperactivity test). Subsequently, brain samples were extracted, and inflammatory mediators were evaluated, including interleukin-6, leukotriene B4, prostaglandin E2, tumor necrosis factor-α, and nuclear phosphorylated-p65. Our findings show NS to result in a marked antimanic-like effect, in tandem with a positive modulation of select inflammatory mediators among male and female rats. The findings reinforce the proposed therapeutic advantages relating to NS ingestion.
Keywords: Nigella sativa; mania; inflammation; behavior; mental illness Nigella sativa; mania; inflammation; behavior; mental illness

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MDPI and ACS Style

Uzzan, S.; Rostevanov, I.-S.; Rubin, E.; Benguigui, O.; Marazka, S.; Kaplanski, J.; Agbaria, R.; Azab, A.N. Chronic Treatment with Nigella sativa Oil Exerts Antimanic Properties and Reduces Brain Inflammation in Rats. Int. J. Mol. Sci. 2024, 25, 1823. https://doi.org/10.3390/ijms25031823

AMA Style

Uzzan S, Rostevanov I-S, Rubin E, Benguigui O, Marazka S, Kaplanski J, Agbaria R, Azab AN. Chronic Treatment with Nigella sativa Oil Exerts Antimanic Properties and Reduces Brain Inflammation in Rats. International Journal of Molecular Sciences. 2024; 25(3):1823. https://doi.org/10.3390/ijms25031823

Chicago/Turabian Style

Uzzan, Sarit, Ira-Sivan Rostevanov, Elina Rubin, Olivia Benguigui, Said Marazka, Jacob Kaplanski, Riad Agbaria, and Abed N. Azab. 2024. "Chronic Treatment with Nigella sativa Oil Exerts Antimanic Properties and Reduces Brain Inflammation in Rats" International Journal of Molecular Sciences 25, no. 3: 1823. https://doi.org/10.3390/ijms25031823

APA Style

Uzzan, S., Rostevanov, I.-S., Rubin, E., Benguigui, O., Marazka, S., Kaplanski, J., Agbaria, R., & Azab, A. N. (2024). Chronic Treatment with Nigella sativa Oil Exerts Antimanic Properties and Reduces Brain Inflammation in Rats. International Journal of Molecular Sciences, 25(3), 1823. https://doi.org/10.3390/ijms25031823

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