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Volume 24
Issue 14
10.3390/ijms241411546
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Article
Peer-Review Record

Suppression of NASH-Related HCC by Farnesyltransferase Inhibitor through Inhibition of Inflammation and Hypoxia-Inducible Factor-1α Expression

Int. J. Mol. Sci. 2023, 24(14), 11546; https://doi.org/10.3390/ijms241411546
by Kohei Yamada 1, Tomokazu Tanaka 1,*, Keita Kai 2, Shohei Matsufuji 1, Kotaro Ito 1, Yoshihiko Kitajima 1,3, Tatsuya Manabe 1 and Hirokazu Noshiro 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(14), 11546; https://doi.org/10.3390/ijms241411546
Submission received: 5 June 2023 / Revised: 6 July 2023 / Accepted: 14 July 2023 / Published: 17 July 2023
(This article belongs to the Special Issue Novel Biological Molecules for Cancer Treatments 2.0)

Round 1

Reviewer 1 Report


Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Very interesting study. My main comment is on the need to comment more on the clinical implication of these findings. 
Which are the potential therapeutical targets in this field?

The authors should comment on the impact of other drugs used in this field on HCC occurrence and clinical course, such as statins (cite the recent MA PMID: 32260179)

English grammar should be improved

I recommend grammar revision

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

The revised version of the manuscript is OK. Thank you!

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