Next Article in Journal
Melanin Distribution in Human Skin: Influence of Cytoskeletal, Polarity, and Centrosome-Related Machinery of Stratum basale Keratinocytes
Previous Article in Journal
Combined Transcriptome Analysis Reveals the Ovule Abortion Regulatory Mechanisms in the Female Sterile Line of Pinus tabuliformis Carr.
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 6
10.3390/ijms22063142
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies

by
Inês Serrenho
1,
Miguel Rosado
2,
Alexandra Dinis
3,
Carla M. Cardoso
4,
Mário Grãos
2,5,6,
Bruno Manadas
2,*,† and
Graça Baltazar
1,*,†
1
Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, 6200-506 Covilhã, Portugal
2
CNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal
3
Pediatric Intensive Care Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal
4
Crioestaminal, 3060-197 Cantanhede, Portugal
5
Institute for Interdisciplinary Research, University of Coimbra (IIIUC), 3030-789 Coimbra, Portugal
6
Biocant, Technology Transfer Association, 3060-197 Cantanhede, Portugal
*
Authors to whom correspondence should be addressed.
†
Equal senior contribution.
Int. J. Mol. Sci. 2021, 22(6), 3142; https://doi.org/10.3390/ijms22063142
Submission received: 4 February 2021 / Revised: 12 March 2021 / Accepted: 17 March 2021 / Published: 19 March 2021
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Browse Figures
Review Reports Versions Notes

Abstract

Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity in the perinatal period. This condition results from a period of ischemia and hypoxia to the brain of neonates, leading to several disorders that profoundly affect the daily life of patients and their families. Currently, therapeutic hypothermia (TH) is the standard of care in developing countries; however, TH is not always effective, especially in severe cases of HIE. Addressing this concern, several preclinical studies assessed the potential of stem cell therapy (SCT) for HIE. With this systematic review, we gathered information included in 58 preclinical studies from the last decade, focusing on the ones using stem cells isolated from the umbilical cord blood, umbilical cord tissue, placenta, and bone marrow. Outstandingly, about 80% of these studies reported a significant improvement of cognitive and/or sensorimotor function, as well as decreased brain damage. These results show the potential of SCT for HIE and the possibility of this therapy, in combination with TH, becoming the next therapeutic approach for HIE. Nonetheless, few preclinical studies assessed the combination of TH and SCT for HIE, and the existent studies show some contradictory results, revealing the need to further explore this line of research.
Keywords: hypoxic-ischemic encephalopathy; stem cell therapy; umbilical cord blood cells; umbilical cord tissue; mesenchymal stem/stromal cells; therapeutic hypothermia hypoxic-ischemic encephalopathy; stem cell therapy; umbilical cord blood cells; umbilical cord tissue; mesenchymal stem/stromal cells; therapeutic hypothermia
Graphical Abstract

Share and Cite

MDPI and ACS Style

Serrenho, I.; Rosado, M.; Dinis, A.; M. Cardoso, C.; Grãos, M.; Manadas, B.; Baltazar, G. Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies. Int. J. Mol. Sci. 2021, 22, 3142. https://doi.org/10.3390/ijms22063142

AMA Style

Serrenho I, Rosado M, Dinis A, M. Cardoso C, Grãos M, Manadas B, Baltazar G. Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies. International Journal of Molecular Sciences. 2021; 22(6):3142. https://doi.org/10.3390/ijms22063142

Chicago/Turabian Style

Serrenho, Inês, Miguel Rosado, Alexandra Dinis, Carla M. Cardoso, Mário Grãos, Bruno Manadas, and Graça Baltazar. 2021. "Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies" International Journal of Molecular Sciences 22, no. 6: 3142. https://doi.org/10.3390/ijms22063142

APA Style

Serrenho, I., Rosado, M., Dinis, A., M. Cardoso, C., Grãos, M., Manadas, B., & Baltazar, G. (2021). Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies. International Journal of Molecular Sciences, 22(6), 3142. https://doi.org/10.3390/ijms22063142

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop