Next Article in Journal
Inhibitory Effect of Avenanthramides (Avn) on Tyrosinase Activity and Melanogenesis in α-MSH-Activated SK-MEL-2 Cells: In Vitro and In Silico Analysis
Next Article in Special Issue
The Evolving Roles of Cardiac Macrophages in Homeostasis, Regeneration, and Repair
Previous Article in Journal
Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective
Previous Article in Special Issue
Cardiomyocyte Proliferation as a Source of New Myocyte Development in the Adult Heart
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 15
10.3390/ijms22157813
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Bmi1 Augments Proliferation and Survival of Cortical Bone-Derived Stem Cells after Injury through Novel Epigenetic Signaling via Histone 3 Regulation

Int. J. Mol. Sci. 2021, 22(15), 7813; https://doi.org/10.3390/ijms22157813
by Lindsay Kraus 1, Chris Bryan 1, Marcus Wagner 1, Tabito Kino 1, Melissa Gunchenko 1, Wassy Jalal 1, Mohsin Khan 2 and Sadia Mohsin 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(15), 7813; https://doi.org/10.3390/ijms22157813
Submission received: 25 June 2021 / Revised: 14 July 2021 / Accepted: 21 July 2021 / Published: 22 July 2021
(This article belongs to the Special Issue Cardiac Repair and Regeneration: New Molecular Mechanisms and Therapeutics)

Round 1

Reviewer 1 Report

Comments:

Overall, excellent study and presentation of novel discoveries. 

Perhaps, add to the title something regarding "novel epigenetic signaling via Histone 3 regulation" as this is also a significant finding in this study.

Figure 5C deserves a separate Figure heading as it is a nice depiction of the signaling pathway. This should be discussed more in the Discussion, or at least referenced instead of Lines 150-153. 

Line 209-210: I do not understand this line. What do you mean by role of Bmi1 role being modest?

Revisions:

Lines 12-14 to: Change to "Multiple stem cell types have been safely transferred into failing human hearts, but the overall clinical cardiovascular benefits have been modest."

Line 15: "have enhanced" to "enhance"

Line 26: "Concluding, that" to "In conclusion,"

Line 36: insert "often" before "irreversible"

Lines 75-82: Eliminate completely as this is a description of results which does not belong in the introduction section. 

Lines 111-112: Eliminate completely as this is a summarizing statement, does not belong in results section. 

Figure 4 caption, Line 181: Change "infected the" to "transduced with"

Line 195: Change "mechanism" to "mechanisms"

Line 223: "mark"??

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Lindsay et al submitted “Bmi-1 augments proliferation and survival of cortical bone derived stem cells after injury” for peer review. They concluded that CBSCs overexpress Bmi1 compared to other stem cells types, which enhanced the regulation of cellular proliferation, DNA damage, and cell cycle. This study was well designed. Results from this study supported their hypothesis. A revision is suggested.

  1. Please address the clinical limitations in this study.
  2. Please emphasize the clinical implications of this study.
  3. Please accurate to the third decimal place of p value.
  4. Please address RFC in each figure legends.
  5. Please quantify Fig3C（three repetitions）.
  6. Please address how many repetitions for each assay in figure legends.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

My questions had been well addressed. 

Back to TopTop