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Stem Cell Activation in Adult Organisms
Review

Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System

Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Cheras 56000, Malaysia
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Author to whom correspondence should be addressed.
Academic Editors: Daniela Salvatori and Wilhelm Bloch
Int. J. Mol. Sci. 2021, 22(11), 5749; https://doi.org/10.3390/ijms22115749
Received: 20 April 2021 / Revised: 22 May 2021 / Accepted: 24 May 2021 / Published: 27 May 2021
(This article belongs to the Special Issue Stem Cell Activation in Adult Organism 2.0)
Rapid growth of the geriatric population has been made possible with advancements in pharmaceutical and health sciences. Hence, age-associated diseases are becoming more common. Aging encompasses deterioration of the immune system, known as immunosenescence. Dysregulation of the immune cell production, differentiation, and functioning lead to a chronic subclinical inflammatory state termed inflammaging. The hallmarks of the aging immune system are decreased naïve cells, increased memory cells, and increased serum levels of pro-inflammatory cytokines. Mesenchymal stem cell (MSC) transplantation is a promising solution to halt immunosenescence as the cells have excellent immunomodulatory functions and low immunogenicity. This review compiles the present knowledge of the causes and changes of the aging immune system and the potential of MSC transplantation as a regenerative therapy for immunosenescence. View Full-Text
Keywords: mesenchymal stem cells; aging; inflammaging; frailty; immune system mesenchymal stem cells; aging; inflammaging; frailty; immune system
MDPI and ACS Style

Yeo, G.E.C.; Ng, M.H.; Nordin, F.B.; Law, J.X. Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System. Int. J. Mol. Sci. 2021, 22, 5749. https://doi.org/10.3390/ijms22115749

AMA Style

Yeo GEC, Ng MH, Nordin FB, Law JX. Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System. International Journal of Molecular Sciences. 2021; 22(11):5749. https://doi.org/10.3390/ijms22115749

Chicago/Turabian Style

Yeo, Genieve E.C., Min H. Ng, Fazlina B. Nordin, and Jia X. Law. 2021. "Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System" International Journal of Molecular Sciences 22, no. 11: 5749. https://doi.org/10.3390/ijms22115749

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