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Volume 22
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Review

Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens

by
Sabina Kędzierska-Mieszkowska
1,* and
Michal Zolkiewski
2
1
Department of General and Medical Biochemistry, Faculty of Biology, University of Gdańsk, 80-308 Gdańsk, Poland
2
Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(10), 5319; https://doi.org/10.3390/ijms22105319
Submission received: 28 April 2021 / Revised: 14 May 2021 / Accepted: 15 May 2021 / Published: 18 May 2021
(This article belongs to the Special Issue Research on Molecular Chaperones: Role and Targeting in Health and Disease)
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Abstract

This review focuses on the molecular chaperone ClpB that belongs to the Hsp100/Clp subfamily of the AAA+ ATPases and its biological function in selected bacterial pathogens, causing a variety of human infectious diseases, including zoonoses. It has been established that ClpB disaggregates and reactivates aggregated cellular proteins. It has been postulated that ClpB’s protein disaggregation activity supports the survival of pathogenic bacteria under host-induced stresses (e.g., high temperature and oxidative stress), which allows them to rapidly adapt to the human host and establish infection. Interestingly, ClpB may also perform other functions in pathogenic bacteria, which are required for their virulence. Since ClpB is not found in human cells, this chaperone emerges as an attractive target for novel antimicrobial therapies in combating bacterial infections.
Keywords: bacteria; ClpB; human; infection; molecular chaperone; pathogen; virulence bacteria; ClpB; human; infection; molecular chaperone; pathogen; virulence

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MDPI and ACS Style

Kędzierska-Mieszkowska, S.; Zolkiewski, M. Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens. Int. J. Mol. Sci. 2021, 22, 5319. https://doi.org/10.3390/ijms22105319

AMA Style

Kędzierska-Mieszkowska S, Zolkiewski M. Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens. International Journal of Molecular Sciences. 2021; 22(10):5319. https://doi.org/10.3390/ijms22105319

Chicago/Turabian Style

Kędzierska-Mieszkowska, Sabina, and Michal Zolkiewski. 2021. "Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens" International Journal of Molecular Sciences 22, no. 10: 5319. https://doi.org/10.3390/ijms22105319

APA Style

Kędzierska-Mieszkowska, S., & Zolkiewski, M. (2021). Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens. International Journal of Molecular Sciences, 22(10), 5319. https://doi.org/10.3390/ijms22105319

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