Next Article in Journal
Identification and Expression Analysis of Hormone Biosynthetic and Metabolism Genes in the 2OGD Family for Identifying Genes That May Be Involved in Tomato Fruit Ripening
Previous Article in Journal
Hormonal Effects on Hair Follicles
Previous Article in Special Issue
CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets

The Role of CDKs and CDKIs in Murine Development

Epigenetic Mechanisms of Toxicology Lab, MRC Toxicology Unit, Cambridge University, Cambridge CB2 1QR, UK
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5343;
Received: 8 July 2020 / Revised: 22 July 2020 / Accepted: 26 July 2020 / Published: 28 July 2020
(This article belongs to the Special Issue Cyclin-Dependent Kinases in Health and Diseases)
Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are essential for appropriate embryonic development. The twenty known mouse CDKs and eight CDKIs have been studied to varying degrees in the developing mouse, but only a handful of CDKs and a single CDKI have been shown to be absolutely required for murine embryonic development. What has become apparent, as more studies have shone light on these family members, is that in addition to their primary functional role in regulating the cell cycle, many of these genes are also controlling specific cell fates by directing differentiation in various tissues. Here we review the extensive mouse models that have been generated to study the functions of CDKs and CDKIs, and discuss their varying roles in murine embryonic development, with a particular focus on the brain, pancreas and fertility. View Full-Text
Keywords: cyclin-dependent kinase; CDK inhibitors; mouse; development; knock-out models cyclin-dependent kinase; CDK inhibitors; mouse; development; knock-out models
Show Figures

Figure 1

MDPI and ACS Style

Campbell, G.J.; Hands, E.L.; Van de Pette, M. The Role of CDKs and CDKIs in Murine Development. Int. J. Mol. Sci. 2020, 21, 5343.

AMA Style

Campbell GJ, Hands EL, Van de Pette M. The Role of CDKs and CDKIs in Murine Development. International Journal of Molecular Sciences. 2020; 21(15):5343.

Chicago/Turabian Style

Campbell, Grace J., Emma L. Hands, and Mathew Van de Pette. 2020. "The Role of CDKs and CDKIs in Murine Development" International Journal of Molecular Sciences 21, no. 15: 5343.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop