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The Role of CDKs and CDKIs in Murine Development

Epigenetic Mechanisms of Toxicology Lab, MRC Toxicology Unit, Cambridge University, Cambridge CB2 1QR, UK
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Int. J. Mol. Sci. 2020, 21(15), 5343; https://doi.org/10.3390/ijms21155343
Received: 8 July 2020 / Revised: 22 July 2020 / Accepted: 26 July 2020 / Published: 28 July 2020
(This article belongs to the Special Issue Cyclin-Dependent Kinases in Health and Diseases)
Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are essential for appropriate embryonic development. The twenty known mouse CDKs and eight CDKIs have been studied to varying degrees in the developing mouse, but only a handful of CDKs and a single CDKI have been shown to be absolutely required for murine embryonic development. What has become apparent, as more studies have shone light on these family members, is that in addition to their primary functional role in regulating the cell cycle, many of these genes are also controlling specific cell fates by directing differentiation in various tissues. Here we review the extensive mouse models that have been generated to study the functions of CDKs and CDKIs, and discuss their varying roles in murine embryonic development, with a particular focus on the brain, pancreas and fertility. View Full-Text
Keywords: cyclin-dependent kinase; CDK inhibitors; mouse; development; knock-out models cyclin-dependent kinase; CDK inhibitors; mouse; development; knock-out models
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MDPI and ACS Style

Campbell, G.J.; Hands, E.L.; Van de Pette, M. The Role of CDKs and CDKIs in Murine Development. Int. J. Mol. Sci. 2020, 21, 5343. https://doi.org/10.3390/ijms21155343

AMA Style

Campbell GJ, Hands EL, Van de Pette M. The Role of CDKs and CDKIs in Murine Development. International Journal of Molecular Sciences. 2020; 21(15):5343. https://doi.org/10.3390/ijms21155343

Chicago/Turabian Style

Campbell, Grace J., Emma L. Hands, and Mathew Van de Pette. 2020. "The Role of CDKs and CDKIs in Murine Development" International Journal of Molecular Sciences 21, no. 15: 5343. https://doi.org/10.3390/ijms21155343

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