Special Issue "Cyclin-Dependent Kinases in Health and Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 18444
Interests: protein kinases; cell cycle; cancer; fluorescent biosensors; allosteric inhibitors
Special Issues, Collections and Topics in MDPI journals
Cyclin-dependent kinases (CDK/Cyclins) were first discovered for their role in the coordination of cell growth and division almost 50 years ago thanks to the independent, yet converging, results of biochemists and yeast geneticists seeking to understand the molecular mechanisms and identify the molecular components governing cell cycle progression. Following a Nobel Prize in Physiology and Medicine in 2001 recognizing the importance of CDK/Cyclins and almost five decades of research, our understanding of this family of serine/threonine protein kinases has grown to provide insight into the diversity/multiplicity and complexity of functions in human physiology, as well as the pathological implications consequent to their deregulation. Together with these studies, characterization of the structural features and mechanisms of regulation of CDK/Cyclins have culminated into the development of drugs which have been approved by the FDA for cancer therapeutics over the last few years.
This Special Issue will cover and focus on the role of CDK/Cyclins in various pathologies in particular cancer and neurodegenerative diseases and on the emerging therapeutics to target these kinases.
Dr. May C. Morris
Manuscript Submission Information
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- Cyclin-dependent kinases
- Cell cycle coordination