You are currently on the new version of our website. Access the old version .

International Journal of Molecular Sciences, Volume 21, Issue 11

2020 June-1 - 452 articles

Cover Story: Bone morphogenetic proteins (BMPs) are multifunctional secreted signaling molecules that act in a highly context-dependent fashion. Interaction of BMPs to their cognate receptors is tightly controlled by a diverse set of secreted BMP antagonists. Perturbations of BMP antagonist expression are implicated in a range of human diseases and disorders, including cancer. Here, we review how BMP antagonists are involved in cancer initiation and progression not only by affecting the cancer cells themselves, but also other crucial cell types in the tumor microenvironment. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (452)

  • Review
  • Open Access
62 Citations
13,607 Views
15 Pages

Regulatory Mechanisms of Somatostatin Expression

  • Emmanuel Ampofo,
  • Lisa Nalbach,
  • Michael D. Menger and
  • Matthias W. Laschke

Somatostatin is a peptide hormone, which most commonly is produced by endocrine cells and the central nervous system. In mammals, somatostatin originates from pre-prosomatostatin and is processed to a shorter form, i.e., somatostatin-14, and a longer...

  • Review
  • Open Access
36 Citations
8,937 Views
22 Pages

G-quadruplexes are four-stranded helical nucleic acid structures formed by guanine-rich sequences. A considerable number of studies have revealed that these noncanonical structural motifs are widespread throughout the genome and transcriptome of nume...

  • Review
  • Open Access
21 Citations
9,238 Views
37 Pages

The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma

  • Wioletta Rozpędek-Kamińska,
  • Radosław Wojtczak,
  • Jacek P. Szaflik,
  • Jerzy Szaflik and
  • Ireneusz Majsterek

Glaucoma is a heterogenous, chronic, progressive group of eye diseases, which results in irreversible loss of vision. There are several types of glaucoma, whereas the primary open-angle glaucoma (POAG) constitutes the most common type of glaucoma, ac...

  • Article
  • Open Access
22 Citations
4,086 Views
14 Pages

The Effect of Substituted Benzene-Sulfonamides and Clinically Licensed Drugs on the Catalytic Activity of CynT2, a Carbonic Anhydrase Crucial for Escherichia coli Life Cycle

  • Sonia Del Prete,
  • Viviana De Luca,
  • Silvia Bua,
  • Alessio Nocentini,
  • Vincenzo Carginale,
  • Claudiu T. Supuran and
  • Clemente Capasso

Proteins are relevant antimicrobial drug targets, and among them, enzymes represent a significant group, since most of them catalyze reactions essential for supporting the central metabolism, or are necessary for the pathogen vitality. Genomic explor...

  • Article
  • Open Access
25 Citations
4,370 Views
16 Pages

Graphene Oxide Scaffold Stimulates Differentiation and Proangiogenic Activities of Myogenic Progenitor Cells

  • Mateusz Wierzbicki,
  • Anna Hotowy,
  • Marta Kutwin,
  • Sławomir Jaworski,
  • Jaśmina Bałaban,
  • Malwina Sosnowska,
  • Barbara Wójcik,
  • Aleksandra Wędzińska,
  • André Chwalibog and
  • Ewa Sawosz

The physiological process of muscle regeneration is quite limited due to low satellite cell quantity and also the inability to regenerate and reconstruct niche tissue. The purpose of the study was to examine whether a graphene oxide scaffold is able...

  • Article
  • Open Access
9 Citations
4,507 Views
12 Pages

Bioshell Calcium Oxide (BiSCaO) Ointment for the Disinfection and Healing of Pseudomonas aeruginosa-Infected Wounds in Hairless Rats

  • Tomohiro Takayama,
  • Masayuki Ishihara,
  • Shingo Nakamura,
  • Yoko Sato,
  • Sumiyo Hiruma,
  • Koichi Fukuda,
  • Kaoru Murakami and
  • Hidetaka Yokoe

Bioshell calcium oxide (BiSCaO) possesses deodorizing properties and broad microbicidal activity. This study aimed to investigate the application of BiSCaO ointment for the prevention and treatment of infection in chronic wounds in healing-impaired p...

  • Article
  • Open Access
17 Citations
3,687 Views
17 Pages

Serum Biomarkers of Cardiovascular Remodelling Reflect Extra-Valvular Cardiac Damage in Patients with Severe Aortic Stenosis

  • Laura Bäz,
  • Gudrun Dannberg,
  • Katja Grün,
  • Julian Westphal,
  • Sven Möbius-Winkler,
  • Christian Jung,
  • Alexander Pfeil,
  • P. Christian Schulze and
  • Marcus Franz

In patients with aortic stenosis (AS), a novel staging classification of extra-valvular left and right heart damage with prognostic relevance was introduced in 2017. The aim of the study was to evaluate the biomarkers of cardiovascular tissue remodel...

  • Review
  • Open Access
98 Citations
9,939 Views
25 Pages

Intracellular calcium (Ca2+) concentration ([Ca2+]i) is a key determinant of cell fate and is implicated in carcinogenesis. Membrane ion channels are structures through which ions enter or exit the cell, depending on the driving forces. The opening o...

  • Article
  • Open Access
22 Citations
5,950 Views
19 Pages

Innate Immune Response against Staphylococcus aureus Preincubated with Subinhibitory Concentration of trans-Anethole

  • Paweł Kwiatkowski,
  • Bartosz Wojciuk,
  • Iwona Wojciechowska-Koszko,
  • Łukasz Łopusiewicz,
  • Bartłomiej Grygorcewicz,
  • Agata Pruss,
  • Monika Sienkiewicz,
  • Karol Fijałkowski,
  • Edward Kowalczyk and
  • Barbara Dołęgowska

The study aimed to analyze morphological and functional changes of Staphylococcus aureus cells due to trans-anethole (a terpenoid and the major constituent of fennel, anise, or star anise essential oils) exposition, and their consequences for human n...

  • Article
  • Open Access
19 Citations
3,963 Views
16 Pages

Characterization of CD4-Positive Lymphocytes in the Antiviral Response of Olive Flounder (Paralichthys oliveceus) to Nervous Necrosis Virus

  • Jae Wook Jung,
  • Jin Hong Chun,
  • Jung Seok Lee,
  • Si Won Kim,
  • Ae Rin Lee,
  • Jaesung Kim,
  • Jassy Mary S. Lazarte,
  • Young Rim Kim,
  • Hyoung Jun Kim and
  • Tae Sung Jung
  • + 1 author

The presence of CD4 T lymphocytes has been described for several teleost species, while many of the main T cell subsets have not been characterized at a cellular level, because of a lack of suitable tools for their identification, e.g., monoclonal an...

of 46

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Int. J. Mol. Sci. - ISSN 1422-0067