Table of Contents
Int. J. Mol. Sci., Volume 21, Issue 11 (June-1 2020) – 452 articles
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Cover Story (view full-size image) Bone morphogenetic proteins (BMPs) are multifunctional secreted signaling molecules that act in a [...] Read more. Bone morphogenetic proteins (BMPs) are multifunctional secreted signaling molecules that act in a highly context-dependent fashion. Interaction of BMPs to their cognate receptors is tightly controlled by a diverse set of secreted BMP antagonists. Perturbations of BMP antagonist expression are implicated in a range of human diseases and disorders, including cancer. Here, we review how BMP antagonists are involved in cancer initiation and progression not only by affecting the cancer cells themselves, but also other crucial cell types in the tumor microenvironment. View this paper