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International Journal of Molecular Sciences, Volume 21, Issue 11

June-1 2020 - 452 articles

Cover Story: Bone morphogenetic proteins (BMPs) are multifunctional secreted signaling molecules that act in a highly context-dependent fashion. Interaction of BMPs to their cognate receptors is tightly controlled by a diverse set of secreted BMP antagonists. Perturbations of BMP antagonist expression are implicated in a range of human diseases and disorders, including cancer. Here, we review how BMP antagonists are involved in cancer initiation and progression not only by affecting the cancer cells themselves, but also other crucial cell types in the tumor microenvironment. View this paper
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Articles (452)

  • Article
  • Open Access
45 Citations
4,778 Views
14 Pages

Identification of circRNA-Associated-ceRNA Networks Involved in Milk Fat Metabolism under Heat Stress

  • Dongyang Wang,
  • Zujing Chen,
  • Xiaona Zhuang,
  • Junyi Luo,
  • Ting Chen,
  • Qianyun Xi,
  • Yongliang Zhang and
  • Jiajie Sun

Summer temperatures are generally high in Southern China, and cows are likely to suffer a heat stress reaction. Heat stress will have a negative impact on the performance of dairy cows; however, the mechanism by which high temperature affects lactati...

  • Article
  • Open Access
23 Citations
4,311 Views
17 Pages

Ectopic Expression of OsPYL/RCAR7, an ABA Receptor Having Low Signaling Activity, Improves Drought Tolerance without Growth Defects in Rice

  • Nikita Bhatnagar,
  • Rigyeong Kim,
  • Seungsu Han,
  • Jaeeun Song,
  • Gang Seob Lee,
  • Sangho Lee,
  • Myung Ki Min and
  • Beom-Gi Kim

Overexpression of abscisic acid (ABA) receptors has been reported to enhance drought tolerance, but also to cause stunted growth and decreased crop yield. Here, we constructed transgenic rice for all monomeric ABA receptors and observed that only tra...

  • Review
  • Open Access
18 Citations
5,143 Views
17 Pages

Over the past decades, the discovery and development of genetically encoded fluorescent proteins (FPs) has brought a revolution into our ability to study biologic phenomena directly within living matter. First, FPs enabled fluorescence-labeling of a...

  • Article
  • Open Access
8 Citations
3,525 Views
14 Pages

Septoria Leaf Blotch and Reduced Nitrogen Availability Alter WRKY Transcription Factor Expression in a Codependent Manner

  • Alistair A. Poll,
  • Jack Lee,
  • Roy A. Sanderson,
  • Ed Byrne,
  • John A. Gatehouse,
  • Ari Sadanandom,
  • Angharad M. R. Gatehouse and
  • Martin G. Edwards

A major cause of yield loss in wheat worldwide is the fungal pathogen Zymoseptoria tritici, a hemibiotrophic fungus which causes Septoria leaf blotch, the most destructive wheat disease in Europe. Resistance in commercial wheat varieties is poor, how...

  • Article
  • Open Access
55 Citations
6,404 Views
18 Pages

Purple-leaf tea is a phenotype with unique color because of its high anthocyanin content. The special flavor of purple-leaf tea is highly different from that of green-leaf tea, and its main ingredient is also of economic value. To probe the genetic m...

  • Review
  • Open Access
20 Citations
4,638 Views
12 Pages

Prion Protein in Stem Cells: A Lipid Raft Component Involved in the Cellular Differentiation Process

  • Stefano Martellucci,
  • Costantino Santacroce,
  • Francesca Santilli,
  • Valeria Manganelli,
  • Maurizio Sorice and
  • Vincenzo Mattei

The prion protein (PrP) is an enigmatic molecule with a pleiotropic effect on different cell types; it is localized stably in lipid raft microdomains and it is able to recruit downstream signal transduction pathways by its interaction with various bi...

  • Article
  • Open Access
16 Citations
6,092 Views
15 Pages

Ultrastructural Location and Interactions of the Immunoglobulin Receptor Binding Sequence within Fibrillar Type I Collagen

  • Jie Zhu,
  • Rama S. Madhurapantula,
  • Aruna Kalyanasundaram,
  • Tanya Sabharwal,
  • Olga Antipova,
  • Sandra W. Bishnoi and
  • Joseph P. R. O. Orgel

Collagen type I is a major constituent of animal bodies. It is found in large quantities in tendon, bone, skin, cartilage, blood vessels, bronchi, and the lung interstitium. It is also produced and accumulates in large amounts in response to certain...

  • Article
  • Open Access
40 Citations
5,350 Views
19 Pages

It is not known how biological changes in the lacrimal (LGs) and meibomian (MGs) glands contribute to dry eye disease (DED) in a time-dependent manner. In this study, we investigated time-sequenced changes in the inflammation, oxidative stress, and s...

  • Review
  • Open Access
62 Citations
13,455 Views
15 Pages

Regulatory Mechanisms of Somatostatin Expression

  • Emmanuel Ampofo,
  • Lisa Nalbach,
  • Michael D. Menger and
  • Matthias W. Laschke

Somatostatin is a peptide hormone, which most commonly is produced by endocrine cells and the central nervous system. In mammals, somatostatin originates from pre-prosomatostatin and is processed to a shorter form, i.e., somatostatin-14, and a longer...

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Int. J. Mol. Sci. - ISSN 1422-0067