Next Article in Journal
Ether-Oxygen Containing Electrospun Microfibrous and Sub-Microfibrous Scaffolds Based on Poly(butylene 1,4-cyclohexanedicarboxylate) for Skeletal Muscle Tissue Engineering
Next Article in Special Issue
Skin Pigmentation: Is the Control of Melanogenesis a Target within Reach?
Previous Article in Journal
Aquaporins Alteration Profiles Revealed Different Actions of Senna, Sennosides, and Sennoside A in Diarrhea-Rats
Previous Article in Special Issue
Zerumbone, a Tropical Ginger Sesquiterpene of Zingiber officinale Roscoe, Attenuates α-MSH-Induced Melanogenesis in B16F10 Cells
Open AccessArticle

Pulsed Electromagnetic Fields Increase Pigmentation through the p-ERK/p-p38 Pathway in Zebrafish (Danio rerio)

1
Department of Medical Biotechnology (BK21 Plus Team), Dongguk University, Goyang-si 10326, Korea
2
R&D Center, NOWCOS, Seoul 08506, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 3211; https://doi.org/10.3390/ijms19103211
Received: 16 August 2018 / Revised: 15 October 2018 / Accepted: 15 October 2018 / Published: 17 October 2018
(This article belongs to the Special Issue Melanins and Melanogenesis: From Nature to Applications)
Melanogenesis is a biological process resulting in the production of melanin pigment, which plays an important role in the prevention of sun-induced skin injury, and determines hair and skin color. So, a wide variety of approaches have been proposed to increase the synthesis of melanin. This study evaluated the effects of pulsed electromagnetic fields (PEMFs) on the pigmentation of zebrafish (Danio rerio) in vivo. We stimulated pigmentation in zebrafish by using specific frequencies and intensities of PEMFs. This study focuses on pigmentation using PEMFs, and finds that PEMFs, at an optimal intensity and frequency, upregulate pigmentation by the stimulated expression of tyrosinase-related protein 1 (TRP1), dopachrome tautomerase (DCT) through extracellular signal-regulated kinase(ERK) phosphorylation, and p38 phosphorylation signaling pathways in zebrafish. These results suggest that PEMFs, at an optimal intensity and frequency, are a useful tool in treating gray hair, with reduced melanin synthesis in the hair shaft or hypopigmentation-related skin disorders. View Full-Text
Keywords: pigmentation; melanogenesis; electromagnetic field; zebrafish; Danio rerio; vitiligo pigmentation; melanogenesis; electromagnetic field; zebrafish; Danio rerio; vitiligo
Show Figures

Figure 1

MDPI and ACS Style

Kim, Y.-M.; Lim, H.-M.; Ro, H.-S.; Ki, G.-E.; Seo, Y.-K. Pulsed Electromagnetic Fields Increase Pigmentation through the p-ERK/p-p38 Pathway in Zebrafish (Danio rerio). Int. J. Mol. Sci. 2018, 19, 3211.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop