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Open AccessArticle

Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.

1
Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan 426-744, Korea
2
Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon 323-833, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(11), 20045-20053; https://doi.org/10.3390/ijms151120045
Received: 11 September 2014 / Revised: 21 October 2014 / Accepted: 23 October 2014 / Published: 4 November 2014
(This article belongs to the Section Biochemistry)
Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI50 values down to 5.2 μM) against six human cancer cell lines. View Full-Text
Keywords: sponge; Scalarispongia; sesterterpenoid; scalarane; cytotoxicity sponge; Scalarispongia; sesterterpenoid; scalarane; cytotoxicity
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Lee, Y.-J.; Lee, J.-W.; Lee, D.-G.; Lee, H.-S.; Kang, J.S.; Yun, J. Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.. Int. J. Mol. Sci. 2014, 15, 20045-20053.

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