Next Article in Journal
Oxidative Stress in Diabetes: Implications for Vascular and Other Complications
Next Article in Special Issue
Combination BMSC and Niaspan Treatment of Stroke Enhances White Matter Remodeling and Synaptic Protein Expression in Diabetic Rats
Previous Article in Journal
Effects of Polymorphisms in Pepsinogen (PEP), Amylase (AMY) and Trypsin (TRY) Genes on Food Habit Domestication Traits in Mandarin Fish
Previous Article in Special Issue
Crosstalk between Delta Opioid Receptor and Nerve Growth Factor Signaling Modulates Neuroprotection and Differentiation in Rodent Cell Models
Open AccessArticle

Neuroprotective Effects of Liraglutide for Stroke Model of Rats

Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama 700-8558, Japan
Department of Neurosurgery, Tokai University, Tokyo 151-0063, Japan
Center for Innovative and Translational Medicine, Kochi University Medical School, Nankoku 783-8505, Japan
Department of Neurosurgery, University of South Florida College Medicine, Tampa, FL 12901, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(11), 21513-21524;
Received: 2 September 2013 / Revised: 18 October 2013 / Accepted: 23 October 2013 / Published: 30 October 2013
(This article belongs to the Special Issue Pathology and Treatment of Central Nervous System Diseases)
The number of diabetes mellitus (DM) patients is increasing, and stroke is deeply associated with DM. Recently, neuroprotective effects of glucagon-like peptide-1 (GLP-1) are reported. In this study, we explored whether liraglutide, a GLP-1 analogue exerts therapeutic effects on a rat stroke model. Wistar rats received occlusion of the middle cerebral artery for 90 min. At one hour after reperfusion, liraglutide or saline was administered intraperitoneally. Modified Bederson’s test was performed at 1 and 24 h and, subsequently, rats were euthanized for histological investigation. Peripheral blood was obtained for measurement of blood glucose level and evaluation of oxidative stress. Brain tissues were collected to evaluate the level of vascular endothelial growth factor (VEGF). The behavioral scores of liraglutide-treated rats were significantly better than those of control rats. Infarct volumes of liraglutide-treated rats at were reduced, compared with those of control rats. The level of derivatives of reactive oxygen metabolite was lower in liraglutide-treated rats. VEGF level of liraglutide-treated rats in the cortex, but not in the striatum significantly increased, compared to that of control rats. In conclusion, this is the first study to demonstrate neuroprotective effects of liraglutide on cerebral ischemia through anti-oxidative effects and VEGF upregulation. View Full-Text
Keywords: cerebral ischemia; diabetes mellitus; glucagon-like peptide-1; liraglutide; oxidative stress; stroke; VEGF cerebral ischemia; diabetes mellitus; glucagon-like peptide-1; liraglutide; oxidative stress; stroke; VEGF
Show Figures

MDPI and ACS Style

Sato, K.; Kameda, M.; Yasuhara, T.; Agari, T.; Baba, T.; Wang, F.; Shinko, A.; Wakamori, T.; Toyoshima, A.; Takeuchi, H.; Sasaki, T.; Sasada, S.; Kondo, A.; Borlongan, C.V.; Matsumae, M.; Date, I. Neuroprotective Effects of Liraglutide for Stroke Model of Rats. Int. J. Mol. Sci. 2013, 14, 21513-21524.

AMA Style

Sato K, Kameda M, Yasuhara T, Agari T, Baba T, Wang F, Shinko A, Wakamori T, Toyoshima A, Takeuchi H, Sasaki T, Sasada S, Kondo A, Borlongan CV, Matsumae M, Date I. Neuroprotective Effects of Liraglutide for Stroke Model of Rats. International Journal of Molecular Sciences. 2013; 14(11):21513-21524.

Chicago/Turabian Style

Sato, Kenichiro; Kameda, Masahiro; Yasuhara, Takao; Agari, Takashi; Baba, Tanefumi; Wang, Feifei; Shinko, Aiko; Wakamori, Takaaki; Toyoshima, Atsuhiko; Takeuchi, Hayato; Sasaki, Tatsuya; Sasada, Susumu; Kondo, Akihiko; Borlongan, Cesario V.; Matsumae, Mitsunori; Date, Isao. 2013. "Neuroprotective Effects of Liraglutide for Stroke Model of Rats" Int. J. Mol. Sci. 14, no. 11: 21513-21524.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop