Next Article in Journal
Green Synthesis and Characterization of Silver/Chitosan/Polyethylene Glycol Nanocomposites without any Reducing Agent
Previous Article in Journal
Intermediates in the Protein Folding Process: A Computational Model
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2011, 12(8), 4861-4871;

Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells

Key Laboratory for Molecular Enzymology & Engineering of the Ministry of Education, School of Life Science, Jilin University, Changchun 130023, China
College of Environmental & Biological Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China
The Center for Combinatorial Chemistry and Drug Discovery, the College of Pharmacy, Jilin University, Changchun 130021, China
School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China
Author to whom correspondence should be addressed.
Received: 24 May 2011 / Revised: 5 July 2011 / Accepted: 20 July 2011 / Published: 2 August 2011
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
Full-Text   |   PDF [796 KB, uploaded 19 June 2014]


Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated. Here, we evaluated the inhibitory proliferation effects of Silibinin in pancreatic carcinoma growth and examined whether Silibinin modulates cell cycle and apoptosis. Our results indicate that Silibinin effectively inhibited the pancreatic carcinoma AsPC-1, BxPC-3 and Panc-1 cells’ proliferation and caused apoptosis. Silibinin induced a decrease in S phase and cell cycle arrest in G1 phase in AsPC-1 cells, but had no obvious changes in BxPC-3 and Panc-1 cell cycle. Furthermore, these results suggest that Silibinin might be a candidate chemopreventive agent for pancreatic carcinoma therapy. View Full-Text
Keywords: Silibinin; cell proliferation; apoptosis; cell-cycle arrest; pancreatic cancer Silibinin; cell proliferation; apoptosis; cell-cycle arrest; pancreatic cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Ge, Y.; Zhang, Y.; Chen, Y.; Li, Q.; Chen, J.; Dong, Y.; Shi, W. Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells. Int. J. Mol. Sci. 2011, 12, 4861-4871.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top