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International Journal of Molecular Sciences, Volume 12, Issue 5

May 2011 - 43 articles

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Articles (43)

  • Article
  • Open Access
19 Citations
9,475 Views
15 Pages

24 May 2011

The endo-β-1,4-glucanase gene celE from the anaerobic fungus Orpinomyces PC-2 was placed under the control of an alcohol oxidase promoter (AOX1) in the plasmid pPIC9K, and integrated into the genome of a methylotrophic yeast P. pastoris GS115 by elec...

  • Article
  • Open Access
17 Citations
9,461 Views
13 Pages

24 May 2011

Extractable dietary fiber (DF) plays an important role in nutrition. This study on porridge making with whole grain rye investigated the effect of rest time of flour slurries at room temperature before cooking and amount of flour and salt in the reci...

  • Article
  • Open Access
58 Citations
9,694 Views
12 Pages

23 May 2011

To investigate anticancer effect of lycopene, we examined the effects of lycopene on the oxidative injury and immunity activities of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric cancer rats. The animals were divided into five groups. G...

  • Article
  • Open Access
97 Citations
13,047 Views
14 Pages

Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula

  • Kaline Dantas Magalhaes,
  • Leandro Silva Costa,
  • Gabriel Pereira Fidelis,
  • Ruth Medeiros Oliveira,
  • Leonardo Thiago Duarte Barreto Nobre,
  • Nednaldo Dantas-Santos,
  • Rafael Barros Gomes Camara,
  • Ivan Rui Lopes Albuquerque,
  • Sara Lima Cordeiro and
  • Diego Araujo Sabry
  • + 3 authors

23 May 2011

In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that...

  • Article
  • Open Access
28 Citations
10,556 Views
18 Pages

20 May 2011

A molecularly imprinted polymer (MIP), obtained by precipitation polymerisation with 4-vinylpyridine as the functional monomer, ethylene glycol dimethacrylate as cross-linker, and bisphenol-A (BPA) as template, was prepared. The binding site configur...

  • Review
  • Open Access
153 Citations
21,153 Views
19 Pages

Nanomedicine: Application Areas and Development Prospects

  • Houria Boulaiz,
  • Pablo J. Alvarez,
  • Alberto Ramirez,
  • Juan A. Marchal,
  • Jose Prados,
  • Fernando Rodríguez-Serrano,
  • Macarena Perán,
  • Consolación Melguizo and
  • Antonia Aranega

19 May 2011

Nanotechnology, along with related concepts such as nanomaterials, nanostructures and nanoparticles, has become a priority area for scientific research and technological development. Nanotechnology, i.e., the creation and utilization of materials and...

  • Article
  • Open Access
31 Citations
12,346 Views
13 Pages

Novel Natural Inhibitors of CYP1A2 Identified by in Silico and in Vitro Screening

  • Ruixin Zhu,
  • Liwei Hu,
  • Haiyun Li,
  • Juan Su,
  • Zhiwei Cao and
  • Weidong Zhang

18 May 2011

Inhibition of cytochrome P450 (CYP) is a major cause of herb–drug interactions. The CYP1A2 enzyme plays a major role in the metabolism of drugs in humans. Its broad substrate specificity, as well as its inhibition by a vast array of structurally dive...

  • Review
  • Open Access
976 Citations
47,587 Views
25 Pages

Microfluidic Mixing: A Review

  • Chia-Yen Lee,
  • Chin-Lung Chang,
  • Yao-Nan Wang and
  • Lung-Ming Fu

18 May 2011

The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Broadly...

  • Article
  • Open Access
73 Citations
10,614 Views
15 Pages

18 May 2011

In this research, two types of sulfated polysaccharide derivatives were successfully synthesized. Their antioxidant activities were investigated by employing various established in vitro systems. In addition, the degree of sulfation was evaluated usi...

  • Article
  • Open Access
52 Citations
9,927 Views
14 Pages

KRAS Mutation Detection in Paired Frozen and Formalin-Fixed Paraffin-Embedded (FFPE) Colorectal Cancer Tissues

  • Jérome Solassol,
  • Jeanne Ramos,
  • Evelyne Crapez,
  • Majda Saifi,
  • Alain Mangé,
  • Evelyne Vianès,
  • Pierre-Jean Lamy,
  • Valérie Costes and
  • Thierry Maudelonde

17 May 2011

KRAS mutation has been unambiguously identified as a marker of resistance to cetuximab-based treatment in metastatic colorectal cancer (mCRC) patients. However, most studies of KRAS mutation analysis have been performed using homogenously archived CR...

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Int. J. Mol. Sci. - ISSN 1422-0067