Next Article in Journal
Expression of an Endo-β-1,4-glucanase Gene from Orpinomyces PC-2 in Pichia pastoris
Previous Article in Journal
Lycopene Enhances Antioxidant Enzyme Activities and Immunity Function in N-Methyl-N′-nitro-N-nitrosoguanidine–Induced Gastric Cancer Rats
Open AccessArticle

Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula

1
Laboratory of Biotechnology of Natural Polymers (BIOPOL), Department of Biochemistry, Federal University of Rio Grande do Norte (UFRN), 59020-100 Natal-RN, Brazil
2
Health Post-Graduate Program, Federal University of Rio Grande do Norte (UFRN), 59020-100 Natal-RN, Brazil
3
Federal Institute of Education, Science and Technology of Rio Grande do Norte (IFRN), 59200-000 Santa Cruz-RN, Brazil
*
Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Int. J. Mol. Sci. 2011, 12(5), 3352-3365; https://doi.org/10.3390/ijms12053352
Received: 9 March 2011 / Revised: 11 April 2011 / Accepted: 19 May 2011 / Published: 23 May 2011
(This article belongs to the Section Biochemistry)
In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (~45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progress. View Full-Text
Keywords: fucoidan; brown seaweed; biological activities; sulfated polysaccharides fucoidan; brown seaweed; biological activities; sulfated polysaccharides
MDPI and ACS Style

Magalhaes, K.D.; Costa, L.S.; Fidelis, G.P.; Oliveira, R.M.; Nobre, L.T.D.B.; Dantas-Santos, N.; Camara, R.B.G.; Albuquerque, I.R.L.; Cordeiro, S.L.; Sabry, D.A.; Costa, M.S.S.P.; Alves, L.G.; Rocha, H.A.O. Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula. Int. J. Mol. Sci. 2011, 12, 3352-3365.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop