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Int. J. Mol. Sci. 2010, 11(5), 1991-1998;

Synthesis of 4′,7-Diacetoxyapigenin and Its Apoptotic Induction in Human Hep G2 Cells

College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, China
The Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Guangdong 518055, China
School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, China
Author to whom correspondence should be addressed.
Received: 30 March 2010 / Accepted: 23 April 2010 / Published: 30 April 2010
(This article belongs to the Section Biochemistry)
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In this study, 4′,7-diacetoxyapigenin [4-(7-acetoxy-5-hydroxy-4-oxo-4H-chromen-2-yl) phenyl acetate] was synthesized for the first time. Its chemical structure was identified by UV, ESI-MS, 1H and 13C-NMR. It could inhibit the proliferation of Hep G2 cells in a dose-dependent manner and induce the significant increase of the G0/G1 cell population. After treatment by 4′,7-diacetoxyapigenin, phosphatidylserine of Hep G2 cells could significantly translocate to the surface of the membrane. The increase of an early apoptotic population was observed by both annexin-FITC and PI staining. It was concluded that 4′,7-diacetoxyapigenin not only induced cells to enter into apoptosis, but also affected the progress of the cell cycle. View Full-Text
Keywords: apoptosis; cell cycle; Hep G2; 4′,7-diacetoxyapigenin apoptosis; cell cycle; Hep G2; 4′,7-diacetoxyapigenin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xu, K.; Liu, F.; Liu, B.; Gao, H.; Ning, Z. Synthesis of 4′,7-Diacetoxyapigenin and Its Apoptotic Induction in Human Hep G2 Cells. Int. J. Mol. Sci. 2010, 11, 1991-1998.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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