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Miniaturization in Biocatalysis

IBB–Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001, Lisboa, Portugal
Int. J. Mol. Sci. 2010, 11(3), 858-879;
Received: 7 January 2010 / Revised: 8 February 2010 / Accepted: 9 February 2010 / Published: 2 March 2010
(This article belongs to the Special Issue Biocatalysis)
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The use of biocatalysts for the production of both consumer goods and building blocks for chemical synthesis is consistently gaining relevance. A significant contribution for recent advances towards further implementation of enzymes and whole cells is related to the developments in miniature reactor technology and insights into flow behavior. Due to the high level of parallelization and reduced requirements of chemicals, intensive screening of biocatalysts and process variables has become more feasible and reproducibility of the bioconversion processes has been substantially improved. The present work aims to provide an overview of the applications of miniaturized reactors in bioconversion processes, considering multi-well plates and microfluidic devices, update information on the engineering characterization of the hardware used, and present perspective developments in this area of research. View Full-Text
Keywords: multi-well plates; microreactors; enzyme immobilization; flow reactors; fluidic properties multi-well plates; microreactors; enzyme immobilization; flow reactors; fluidic properties
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Fernandes, P. Miniaturization in Biocatalysis. Int. J. Mol. Sci. 2010, 11, 858-879.

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