Next Article in Journal
Phthalimides: Supramolecular Interactions in Crystals, Hypersensitive Solution 1H-NMR Dynamics and Energy Transfer to Europium(III) and Terbium(III) States
Previous Article in Journal
Microwave Assisted Synthesis, Part 1: Rapid Solventless Synthesis of 3-Substituted Coumarins and Benzocoumarins by Microwave Irradiation of the Corresponding Enaminones
Article Menu

Export Article

Open AccessArticle
Molecules 2003, 8(7), 556-564;

Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents

University of Applied Sciences Basel, Gründenstrasse 40, CH-4132 Muttenz, Switzerland
Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland
Author to whom correspondence should be addressed.
Received: 16 June 2003 / Revised: 25 June 2003 / Accepted: 25 June 2003 / Published: 15 July 2003
Full-Text   |   PDF [52 KB, uploaded 18 June 2014]   |  


A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalarial therapies. Some of the final compounds prepared exhibited encouraging inhibitory activity towards PM II. View Full-Text
Keywords: Malaria; Plasmepsin II; Reductive Amination; Suzuki Coupling Malaria; Plasmepsin II; Reductive Amination; Suzuki Coupling

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Mueller, R.; Huerzeler, M.; Boss, C. Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents. Molecules 2003, 8, 556-564.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top