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Open AccessArticle

Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide

Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, 14040-901 – Ribeirão Preto – SP, Brazil
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Molecules 2000, 5(6), 908-915; https://doi.org/10.3390/50600908
Received: 18 February 2000 / Accepted: 20 June 2000 / Published: 27 June 2000
Goyazensolide, a biologically active natural product classified as a furoheliangolide, was transformed in a phthalimide derivative that showed an enhanced biological activity against Tripanosoma cruzi. The complex natural product was also reduced with high stereoselectivity by hydrogen/Wilkinson’s catalyst; an epimer of this product was obtained in the reduction with hydrogen/Pd-C. View Full-Text
Keywords: Furo-heliangolides; Goyazensolide; Reduction; Phthalimide derivative; Wilkinson’s catalyst Furo-heliangolides; Goyazensolide; Reduction; Phthalimide derivative; Wilkinson’s catalyst
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Da Silva, G.V.J.; Heleno, V.C.G.; Constantino, M.G. Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide. Molecules 2000, 5, 908-915.

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