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Molecules
Volume 26
Issue 4
10.3390/molecules26041074
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Open AccessArticle

Demonstration of Green Solvent Performance on O,S,N-Heterocycles Synthesis: Metal-Free Click Chemistry and Buchwald—Hartwig Coupling

by
Joana F. Campos
1,
Manon Cailler
1,
Remi Claudel
1,
Benjamin Prot
1,
Thierry Besson
2 and
Sabine Berteina-Raboin
1,*
1
Institut de Chimie Organique et Analytique (ICOA), Université d’Orléans UMR-CNRS 7311, BP 6759, Rue de Chartres, 45067 Orléans CEDEX 2, France
2
Normandie Univ., UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France
*
Author to whom correspondence should be addressed.
Academic Editors: Daniele Castagnolo and Vito Capriati
Molecules 2021, 26(4), 1074; https://doi.org/10.3390/molecules26041074
Received: 27 January 2021 / Revised: 15 February 2021 / Accepted: 16 February 2021 / Published: 18 February 2021
(This article belongs to the Special Issue Green Methodologies for the Synthesis of Active Pharmaceutical Ingredients and Drug-Like Compounds)
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Abstract

The development of new and greener approaches to organic synthesis has been a trend in recent years. Continuing the latest publications of our team, in this work, we demonstrate the efficiency of three solvents: eucalyptol (1,8-cineole), cyclopentyl methyl ether (CPME), and 2-methyltetrahydrofuran (2-MeTHF) for the synthesis of O,S,N-heterocyclic compounds. View Full-Text
Keywords: eucalyptol; cyclopentyl methyl ether; 2-methyltetrahydrofuran; O,S,N-heterocycles; greener methodology; green solvent eucalyptol; cyclopentyl methyl ether; 2-methyltetrahydrofuran; O,S,N-heterocycles; greener methodology; green solvent
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MDPI and ACS Style

Campos, J.F.; Cailler, M.; Claudel, R.; Prot, B.; Besson, T.; Berteina-Raboin, S. Demonstration of Green Solvent Performance on O,S,N-Heterocycles Synthesis: Metal-Free Click Chemistry and Buchwald—Hartwig Coupling. Molecules 2021, 26, 1074. https://doi.org/10.3390/molecules26041074

AMA Style

Campos JF, Cailler M, Claudel R, Prot B, Besson T, Berteina-Raboin S. Demonstration of Green Solvent Performance on O,S,N-Heterocycles Synthesis: Metal-Free Click Chemistry and Buchwald—Hartwig Coupling. Molecules. 2021; 26(4):1074. https://doi.org/10.3390/molecules26041074

Chicago/Turabian Style

Campos, Joana F.; Cailler, Manon; Claudel, Remi; Prot, Benjamin; Besson, Thierry; Berteina-Raboin, Sabine. 2021. "Demonstration of Green Solvent Performance on O,S,N-Heterocycles Synthesis: Metal-Free Click Chemistry and Buchwald—Hartwig Coupling" Molecules 26, no. 4: 1074. https://doi.org/10.3390/molecules26041074

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