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Molecules, Volume 22, Issue 3

March 2017 - 163 articles

Cover Story: In the New Medicines for Trypanosomatidic Infections (NMTRypI) project funded by the EU, we have discovered novel anti-leishmania and anti-trypanosoma hits that inhibit pteridine reductase 1 (PTR1). Here, we synthesized compounds with a flavanone scaffold and characterized their antiparasitic activity and ADME-tox properties. Crystal structure determination and computational docking explain differences in their inhibition of PTR1. Two crystal structures of one compound with different PTR1 enzymes provide a basis for further scaffold optimization to develop inhibitors targeting PTR1 enzymes from different parasites. View this paper.
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Articles (163)

  • Review
  • Open Access
299 Citations
19,121 Views
29 Pages

Catechins are natural polyphenolic phytochemicals that exist in food and medicinal plants, such as tea, legume and rubiaceae. An increasing number of studies have associated the intake of catechins-rich foods with the prevention and treatment of chro...

  • Article
  • Open Access
13 Citations
5,873 Views
16 Pages

Synthesis of Randomly Substituted Anionic Cyclodextrins in Ball Milling

  • László Jicsinszky,
  • Marina Caporaso,
  • Emanuela Calcio Gaudino,
  • Cristina Giovannoli and
  • Giancarlo Cravotto

A number of influencing factors mean that the random substitution of cyclodextrins (CD) in solution is difficult to reproduce. Reaction assembly in mechanochemistry reduces the number of these factors. However, lack of water can improve the reaction...

  • Article
  • Open Access
68 Citations
7,910 Views
11 Pages

In Vitro Antioxidant Activity and In Vivo Anti-Fatigue Effect of Sea Horse (Hippocampus) Peptides

  • Zebin Guo,
  • Duanquan Lin,
  • Juanjuan Guo,
  • Yi Zhang and
  • Baodong Zheng

This study investigated changes the in vitro antioxidant activity of Hippocampus polypeptides during enzymatic hydrolysis, including the effects of enzyme species, enzyme concentration, material–liquid ratio, hydrolysis time, pH, and temperature of t...

  • Review
  • Open Access
115 Citations
13,273 Views
18 Pages

Therapeutic Potentials of Microalgae in the Treatment of Alzheimer’s Disease

  • Tosin A. Olasehinde,
  • Ademola O. Olaniran and
  • Anthony I. Okoh

Current research is geared towards the discovery of new compounds with strong neuroprotective potential and few or no side effects compared to synthetic drugs. This review focuses on the potentials of extracts and biologically active compounds derive...

  • Article
  • Open Access
56 Citations
9,232 Views
18 Pages

Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions

  • Rawda M. Okasha,
  • Fawzia F. Alblewi,
  • Tarek H. Afifi,
  • Arshi Naqvi,
  • Ahmed M. Fouda,
  • Al-Anood M. Al-Dies and
  • Ahmed M. El-Agrody

A series of novel 4H-benzo[h]chromenes 4, 6–11, 13, 14; 7H-benzo[h]chromeno[2,3-d]pyrimidines 15–18, 20, and 14H-benzo[h]chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 19a–e, 24 was prepared. The structures of the synthesized compounds w...

  • Article
  • Open Access
40 Citations
14,886 Views
20 Pages

Intramolecular hydrogen bonding (HB) is one of the most studied noncovalent interactions of molecules. Many physical, spectral, and topological properties of compounds are under the influence of HB, and there are many parameters used to notice and to...

  • Article
  • Open Access
41 Citations
9,062 Views
12 Pages

The antibacterial activity of pterostilbene in combination with gentamicin against six strains of Gram-positive and Gram-negative bacteria were investigated. The minimum inhibitory concentration and minimum bactericidal concentration of pterostilbene...

  • Article
  • Open Access
80 Citations
9,165 Views
20 Pages

Analysis of Chemical Constituents of Melastoma dodecandrum Lour. by UPLC-ESI-Q-Exactive Focus-MS/MS

  • Jinfeng Wang,
  • Ziyao Jia,
  • Zhihao Zhang,
  • Yutong Wang,
  • Xi Liu,
  • Linghua Wang and
  • Ruichao Lin

The ethnic drug Melastoma dodecandrum Lour. (MDL) is widely distributed throughout South China, and is the major component of Gong Yan Ping Tablets/Capsules and Zi Di Ning Xue San. Although the pharmacological effects of MDL have been well documented...

  • Article
  • Open Access
15 Citations
4,663 Views
9 Pages

Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum

  • Nan-Fu Chen,
  • Yin-Di Su,
  • Tsong-Long Hwang,
  • Zuo-Jian Liao,
  • Kuan-Hao Tsui,
  • Zhi-Hong Wen,
  • Yang-Chang Wu and
  • Ping-Jyun Sung

Three new polyoxygenated briarane diterpenoids, briarenols C–E (1–3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1...

  • Article
  • Open Access
54 Citations
10,818 Views
18 Pages

Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators

  • Samar Said Fatahala,
  • Sherifa Hasabelnaby,
  • Ayman Goudah,
  • Ghada I. Mahmoud and
  • Rania Helmy Abd-El Hameed

A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, 1H-NMR and mass spectroscopy. The final compounds have been screened for in vitro...

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Molecules - ISSN 1420-3049