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Article

Effect of Culture Conditions on Metabolite Production of Xylaria sp.

1
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
2
The First College of Clinical Medical Science, China Three Gorges University, Yichang 443002, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(5), 7940-7950; https://doi.org/10.3390/molecules20057940
Received: 10 March 2015 / Revised: 26 April 2015 / Accepted: 28 April 2015 / Published: 30 April 2015
(This article belongs to the Section Natural Products Chemistry)
Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated. A shift in the production of five known cytochalasin-type analogues 15 to six new α-pyrone derivatives, xylapyrones A–F (compounds 611), from a solid to a liquid medium was observed. These compounds were identified by analysis of 1D and 2D NMR and HRMS data. Compounds 13 showed moderate cytotoxicity against HepG2 and Caski cancer cell lines with IC50 values ranging from 25 to 63 μM and compounds 411 were found to be inactive, with IC50 values >100 μM. View Full-Text
Keywords: Xylaria sp.; cryptic natural product; cytochalasin; α-pyrone; xylapyrones; cytotoxicity Xylaria sp.; cryptic natural product; cytochalasin; α-pyrone; xylapyrones; cytotoxicity
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MDPI and ACS Style

Zhang, H.; Deng, Z.; Guo, Z.; Peng, Y.; Huang, N.; He, H.; Tu, X.; Zou, K. Effect of Culture Conditions on Metabolite Production of Xylaria sp. Molecules 2015, 20, 7940-7950. https://doi.org/10.3390/molecules20057940

AMA Style

Zhang H, Deng Z, Guo Z, Peng Y, Huang N, He H, Tu X, Zou K. Effect of Culture Conditions on Metabolite Production of Xylaria sp. Molecules. 2015; 20(5):7940-7950. https://doi.org/10.3390/molecules20057940

Chicago/Turabian Style

Zhang, Hongqi; Deng, Zhangshuang; Guo, Zhiyong; Peng, Yan; Huang, Nianyu; He, Haibo; Tu, Xuan; Zou, Kun. 2015. "Effect of Culture Conditions on Metabolite Production of Xylaria sp." Molecules 20, no. 5: 7940-7950. https://doi.org/10.3390/molecules20057940

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