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Molecules 2012, 17(5), 5396-5403;

Two New Cyanogenic Glucosides from the Leaves of Hydrangea macrophylla

College of Pharmacy, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, China
Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China
Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
Author to whom correspondence should be addressed.
Received: 27 March 2012 / Revised: 22 April 2012 / Accepted: 27 April 2012 / Published: 8 May 2012
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Chemical investigation of the ethanol extract of the aerial parts of Hydrangea macrophylla collected in the Sichuan Province of China resulted in the isolation of two new cyanogenic glucosides. Their structures were elucidated as [(2R)-2-(b-D-glucopyranosyloxy)-2-(3,4-dimethoxy-phenyl)] acetonitrile (1) and {(2R)-2-[a-D-glucopyranosyl(1®6)b-D-glucopyranosyloxy]-2-(3-hydroxy-4-methoxy-phenyl)}acetonitrile (2) on the basis of extensive spectroscopic analysis (1D, 2D NMR and HRESIMS) and chemical studies. View Full-Text
Keywords: Hydrangea macrophylla; Saxifragaceae; cyanogenic glucoside Hydrangea macrophylla; Saxifragaceae; cyanogenic glucoside

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Yang, C.-J.; Wang, Z.-B.; Zhu, D.-L.; Yu, Y.; Lei, Y.-T.; Liu, Y. Two New Cyanogenic Glucosides from the Leaves of Hydrangea macrophylla. Molecules 2012, 17, 5396-5403.

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