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Molecules 2012, 17(12), 14058-14066; https://doi.org/10.3390/molecules171214058

Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.

1
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
3
Division of Marine Biotechnology, Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan
4
Department of Life Science, National Taitung University, Taitung 950, Taiwan
5
Industrial Technology Research Institute, Clean Energy and Eco-Technology Center, Tainan 734, Taiwan
6
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
7
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 22 October 2012 / Revised: 18 November 2012 / Accepted: 23 November 2012 / Published: 27 November 2012
(This article belongs to the Section Natural Products Chemistry)
PDF [270 KB, uploaded 18 June 2014]

Abstract

Two norcembranoidal diterpenes, 5-episinuleptolide acetate (1) and scabrolide D (2), were isolated from a Formosan octocoral identified as Sinularia sp. The structures of norcembranoids 1 and 2 were established by spectroscopic methods and by comparison of the spectral data with those of known analogues and 1 was proven to be a new natural product. Norcembranoid 1 was found to exhibit cytotoxicity toward a panel of tumor cells.
Keywords: Sinularia; norcembranoidal diterpene; cytotoxicity Sinularia; norcembranoidal diterpene; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Yen, W.-H.; Hu, L.-C.; Su, J.-H.; Lu, M.-C.; Twan, W.-H.; Yang, S.-Y.; Kuo, Y.-C.; Weng, C.-F.; Lee, C.-H.; Kuo, Y.-H.; Sung, P.-J. Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.. Molecules 2012, 17, 14058-14066.

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