Next Article in Journal
Novel Self-Dyed Wholly Aromatic Polyamide-Hydrazides Covalently Bonded with Azo Groups in Their Main Chains: 1. Structure-Property Relationships
Previous Article in Journal
A Comparative Uptake Study of Multiplexed PET Tracers in Mice with Turpentine-Induced Inflammation
Open AccessArticle

A New Ursane-Type Nor-Triterpenoid from the Leaves of Eucommia ulmoides Oliv.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
*
Author to whom correspondence should be addressed.
Molecules 2012, 17(12), 13960-13968; https://doi.org/10.3390/molecules171213960
Received: 28 September 2012 / Revised: 6 November 2012 / Accepted: 8 November 2012 / Published: 26 November 2012
(This article belongs to the Section Natural Products Chemistry)
A new ursane-type nortriterpenoid, (11S,12S)-4-methyl-11,12-epoxy-2-hydroxy-3-oxoursa-1,4-dine-28-oic acid γ-lactone (1), named ulmoidol A, together with ten known compounds: ulmoidol (2), corosolic acid (3), 2α,3α-dihydroxy-24-nor-4(23),12-oleanadien-28-oic acid (4), oleanolic acid (5), ursolic acid (6), cycloart-3β, 25-diol (7), foliasalacioside B1 (8), (6R,7E,9R)-9-hydroxy-4,7-megastigmadien-3-one-9-O-α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside (9), (6R,7E,9R)-9-hydroxy-4,7-megastigma-dien-3-one-9-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside (10), and quercetin 3-O-sambubioside (11) were isolated from the leaves of Eucommia ulmoides Oliv. The structure of compound 1 was determined by extensive spectroscopic analysis, and its absolute configuration was determined by CD experiments and a computational method. Compounds 3, 4, 710 were isolated from this plant for the first time. Compounds 3 and 4 showed inhibition to PTPIB activities, with IC50 values of 0.69 and 3.98 μM, respectively. View Full-Text
Keywords: Eucommia ulmoides Oliv.; nor-triterpenoid; ulmoidol A; absolute configuration; ECD; PTPIB Eucommia ulmoides Oliv.; nor-triterpenoid; ulmoidol A; absolute configuration; ECD; PTPIB
Show Figures

Figure 1

MDPI and ACS Style

Li, C.; Li, L.; Wang, C.; Yang, J.; Ye, F.; Tian, J.; Si, Y.; Zhang, D. A New Ursane-Type Nor-Triterpenoid from the Leaves of Eucommia ulmoides Oliv.. Molecules 2012, 17, 13960-13968.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop