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Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities

College of Science and Arts at Ar-Rass, Qassim University, P.O. Box 53, Saudi Arabia
Molecules 2011, 16(12), 10292-10302; https://doi.org/10.3390/molecules161210292
Received: 11 November 2011 / Revised: 28 November 2011 / Accepted: 29 November 2011 / Published: 12 December 2011
(This article belongs to the Special Issue Stereoselective Synthesis)
A series of new coumarin derivatives 4 containing a 4-arylbut-3-en-2-one moiety were synthesized by condensation of 3-acetylcoumarin 1 with aryl aldehydes 2 in chloroform in the presence of piperidine. The interactions of 3-formyl-4-chlorocoumarin (3) with nitrogen-containg nucleophiles leading to the corresponding substituted chromen-[4,3-c]pyrazol-4-ones 5 are described. The structures of the obtained compounds were established on the basis of 1D NMR, 2D NMR and IR and further the compounds were evaluated for possible antioxidant activities. The coumarinic chalcone 4a has been found to be the most active (IC50 = 2.07 μM) in this study. View Full-Text
Keywords: coumarin derivatives; chalcone; antioxidant activities coumarin derivatives; chalcone; antioxidant activities
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Al-Ayed, A.S. Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities. Molecules 2011, 16, 10292-10302.

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