Next Article in Journal
Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections
Next Article in Special Issue
3-Acetyloxy-2-cyano-2-(alkylaminocarbamoyl)propyl Groups as Biodegradable Protecting Groups of Nucleoside 5´-mono-Phosphates
Previous Article in Journal
The Relationship between Phenolics and Flavonoids Production with Total Non Structural Carbohydrate and Photosynthetic Rate in Labisia pumila Benth. under High CO2 and Nitrogen Fertilization
Previous Article in Special Issue
Prodrug Approach for Increasing Cellular Glutathione Levels
Article Menu

Export Article

Open AccessArticle
Molecules 2011, 16(1), 175-189;

Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

Programa de Doctorado en Ciencias Biológicas, Universidad Autónoma Metropolitana, México D.F., Mexico
Facultad de Ciencias Químicas-CIEP, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, Mexico
Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana, Unidad Iztapalapa, México D.F., Mexico
Instituto de Química, Universidad Nacional Autónoma de México, México D. F, Mexico
Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco, México D. F., Mexico
Author to whom correspondence should be addressed.
Received: 22 November 2010 / Revised: 24 December 2010 / Accepted: 28 December 2010 / Published: 29 December 2010
(This article belongs to the Special Issue Prodrugs)
Full-Text   |   PDF [147 KB, uploaded 18 June 2014]   |  


A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds. View Full-Text
Keywords: benzimidazole; sulphonamide; MRSA; antibacterial activity benzimidazole; sulphonamide; MRSA; antibacterial activity

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

González-Chávez, M.M.; Méndez, F.; Martínez, R.; Pérez-González, C.; Martínez-Gutiérrez, F. Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity. Molecules 2011, 16, 175-189.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top