Next Article in Journal
Synthesis and Antitumor Activity of 3-Methyl-4-oxo-3,4-dihydroimidazo [5,1-d][1,2,3,5]tetrazine-8-carboxylates and -carboxamides
Previous Article in Journal
Synthesis of 2-(4,6-Dimethoxy-1,3,5-triazin-2-yloxyimino) Derivatives: Application in Solution Peptide Synthesis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 15
Issue 12
10.3390/molecules15129418
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives

by
Yahia Nasser Mabkhot
1,*,
Nabila Abd Elshafy Kheder
2,† and
Abdullah Mohammad Al-Majid
1
1
Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
2
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
*
Author to whom correspondence should be addressed.
†
Current Address: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia
Molecules 2010, 15(12), 9418-9426; https://doi.org/10.3390/molecules15129418
Submission received: 12 October 2010 / Revised: 15 December 2010 / Accepted: 16 December 2010 / Published: 20 December 2010
Browse Figures
Versions Notes

Abstract

:
A facile and convenient synthesis of bis(2-(1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile), bis((3-amino-5-(methylthio)-1H-pyrazol-4-yl)methanone) and bis(2-thioxo-1,2-dihydropyrimidine-5-carbonitrile) derivatives incorporating a thieno- [2,3-b]thiophene moiety via versatile, readily accessible diethyl 3,4-dimethylthieno-[2,3-b]thiophene-2,5-dicarboxylate (1) is described.

1. Introduction

Recently, bis(heterocycles) have received a great deal of attention, not only as model compounds for main chain polymers but also because many biologically active natural and synthetic products have molecular symmetry [1,2,3,4,5,6,7,8]. On the other hand, many thiophene-containing compounds, including annulated compounds, exhibit biological activities [9,10]. Thienothiophene derivatives have been developed for different purposes in the pharmaceutical field and have been tested as potential antitumor, antiviral and antibiotic, antiglaucoma drugs, or as inhibitors of platelet aggregation [11,12,13,14,15]. In addition, thienothiophenes have potential applications in a wide variety of optical and electronic systems [16,17,18]. Encouraged by all these findings and in continuation of our ongoing research program investigating the utilisation of compound 1 as a versatile and useful building block for the synthesis of a wide variety of bis-heterocyclic systems [19,20], we report herein a convenient route to some novel bis-heterocycles derivatives.

2. Results and Discussion

Treatment of 3,3'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(3-oxopropanenitrile) (2) [20] with sodium hydride and carbon disulfide followed by methyl iodide afforded compound 3, which reacted with o-phenylenediamine in refluxing ethanol to give 3,3'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(2-(1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile) (4, Scheme 1). Its IR spectrum revealed two absorption bands at 3,214 and 3,177 cm-1 due to two NH groups and two bands at 2,195 and 1,670 cm-1 assignable to nitrile and carbonyl functions, respectively. The 1H-NMR spectrum of the reaction product displayed singlets at δ 2.49 and 13.1 due to methyls and two NH protons, respectively, in addition to an aromatic multiplet in the δ 7.28–7.59 region. The lack of an active methine proton signal in the 1H-NMR spectrum indicates that it exists exclusively in the 1,3-dihydrobenzimidazol-2-ylidene structure 4, and rules out the isomeric 6. Further evidence for the structure of compound 4 was provided by its alternative synthesis shown in Scheme 1. Thus, treatment of ester 1 [21] with an equimolar quantity of 2-cyanomethyl-1H-benzimidazole in the presence of sodium hydride in benzene under refluxing conditions, followed by neutralisation of the formed salt, afforded a product identical in all respects (mp., mixed mp., IR and MS spectra) with compound 4.
Reaction of the product 3 with hydrazine hydrate gave 3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl-bis-(3-amino-5-(methylthio)-1H-pyrazol-4-yl)methanone (8, Scheme 2). The 1H-NMR spectrum of compound 8 revealed two signals at δ 2.49 and 2.89 due to two CH3 groups, in addition to two D2O-exchangeable signals at δ 5.50 and 7.95 due to NH2 and NH protons, respectively.
Treatment of compound 2 with dimethylformamide-dimethylacetal (DMF-DMA) in refluxing xylene afforded 2-({5-[-2-cyano-3-(dimethylamino)-2-propenoyl]-3,4-dimethylthieno[2,3-b]thiophen-2-yl}carbonyl)-3-(dimethylamino)-2-propenenitrile (9) [20]. When compound 9 was treated with thiourea in refluxing ethanol, the novel 4,4'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(2-thioxo-1,2-dihydropyrimidine-5-carbonitrile) (12) was produced (Scheme 3). The structure of the obtained product was assigned as 12 and not the other expected derivative 14 based on its spectral data. For example, the IR spectrum of the reaction product revealed no absorption bands due to amino groups and revealed absorption bands at 3,200 and 2,210 cm-1 assignable to NH groups and nitrile functions, respectively. The formation of compound 12 is assumed to take place via nucleophilic addition of NH2 in thiourea to the double bond in the enaminone 9 to give the acyclic non-isolable intermediate 10, which underwent intramolecular cyclization with subsequent aromatization via loss of water and dimethylamine molecules to afford the final product 12 (Scheme 3).
Molecules 15 09418 g001 550
Scheme 1. Synthesis of 3,3'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(2-(1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile) (4).
Scheme 1. Synthesis of 3,3'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(2-(1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile) (4).
Molecules 15 09418 g001
Molecules 15 09418 g002 550
Scheme 2. Synthesis of (3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis((3-amino-5-(methylthio)-1H-pyrazol-4-yl)methanone) (8).
Scheme 2. Synthesis of (3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis((3-amino-5-(methylthio)-1H-pyrazol-4-yl)methanone) (8).
Molecules 15 09418 g002
Molecules 15 09418 g003 550
Scheme 3. Synthesis of 4,4'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(2-thioxo-1,2-dihydropyrimidine-5-carbonitrile) (12).
Scheme 3. Synthesis of 4,4'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(2-thioxo-1,2-dihydropyrimidine-5-carbonitrile) (12).
Molecules 15 09418 g003
The nucleophilic addition of the thieno[2,3-b]thiophene 2 to phenyl isothiocyanate in DMF, in the presence of potassium hydroxide, afforded the corresponding potassium salt 15. Heterocyclisation of the intermediate 15 with an equimolar amount of the 2-bromo-1-phenylethanone [22] furnished one isolable product (as verified by TLC analysis). The reaction product was identified as 4,4'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(5-benzoyl-2-(phenylamino)thiophene-3-carbonitrile) (17, Scheme 4). The IR spectrum of compound 17 revealed absorption bands at 1,618, 2,212 and 3,277 cm‑1 due to carbonyl group, nitrile and NH functions, respectively. Its 1H-NMR spectrum showed signals at δ 2.07 due to two CH3 groups and a D2O-exchangeable peak at δ 10.6 due to two NH protons, in addition to an aromatic multiplet in the δ 7.09–7.53 region. The aforementioned results indicate that the reaction of the intermediate 15 with 2-bromo-1-phenylethanone proceeds via loss of two water molecules from the non-isolable intermediate 16 (Scheme 4).
Molecules 15 09418 g004 550
Scheme 4. Synthesis of 4,4'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(5-benzoyl-2-(phenyl- amino)thiophene-3-carbonitrile) (17).
Scheme 4. Synthesis of 4,4'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(5-benzoyl-2-(phenyl- amino)thiophene-3-carbonitrile) (17).
Molecules 15 09418 g004

3. Experimental

General

All melting points were measured on a Gallenkamp melting point apparatus. The infrared spectra were recorded in potassium bromide disks on a Pye Unicam SP 3300 or Shimadzu FT IR 8101 PC infrared spectrophotometers. The NMR spectra were recorded on a Varian Mercury VX-300 NMR spectrometer. 1H spectra were run at 300 MHz and 13C spectra were run at 75.46 MHz in deuterated dimethyl sulfoxide (DMSO-d6). Chemical shifts were related to that of the solvent. Mass spectra were recorded on a Shimadzu GCMS-QP 1000 EX mass spectrometer at 70 e.V. Elemental analyses were carried out at the Microanalytical Center of Cairo University, Giza, Egypt.
2-({5-[2-Cyano-3-(1,1-bis-methythio)-2-propenoyl]-3,4-dimethylthieno[2,3-b]thiophen-2-yl}carbonyl)-3-(1,1-bis-methylthio)-2-propenenitrile (3). To a stirred solution of sodium hydride (0.96 g, 40 mmol) in dimethylsulfoxide (20 mL), compound 2 (3.02 g, 10 mmol) was added. The resulting mixture was stirred for 30 min, and then carbon disulfide (1.52 g, 20 mmol) was added. After 2 h of stirring, methyl iodide (5.68 g, 40 mmol) was added and the stirring was continued for additional 4 h. The resulting reaction mixture was then poured over crushed ice and the solid product was filtered off, washed with water, dried and finally recrystallised from ethanol to afford bis(methylthio)methylene derivative 3 in 60% yield, mp 170 °C; IR (KBr) ν max: 1,698 (C=O), 2,210 (C≡N), 2,985 (aliphatic CH) cm−1. 1H-NMR (DMSO-d6): δ 2.23 (s, 6H, CH3), 2.53 (s, 12H, CH3). Anal. Calcd for C20H18N2O2S6(510.76): C, 47.03; H, 3.55; N, 5.48. Found: C, 47.13; H, 3.48; N, 5.40%.
3,3'-(3,4-Dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(2-(1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxo-propanenitrile) (4) Method A. o-Phenylenediamine (0.22 g, 2 mmol) was added to a solution of bis(methylthio)methylene derivative 3 (0.51 g, 1 mmol) in ethanol (20 mL). The mixture was refluxed for 3 h and then allowed to cool. The solid formed was filtered off, washed with ethanol and recrystallised from DMF/water to afford compound 4 in 72% yield, mp < 320 °C; IR (KBr) ν max: 1,670 (C=O), 2,195 (C≡N), 3,214 and 3,177 (NH) cm−1; 1H-NMR (DMSO-d6): δ 2.49 (s, 6H, 2CH3), 7.28–7.32 (d, 4H, J = 8.7 Hz), 7.56–7.59 (t, 4H, J = 8.7 Hz), 13.1 (s, 4H, D2O-exchangeable, 4NH); 13C-NMR (DMSO-d6): δ 8.3 (2CH3), 111.0 (2=C-C), 115.3 (2CN), 117.6, 118.9, 142.2, 156.0 (benzimidazole ArC), 130.4, 131.8, 138.8, 140.1, (thienothiophene ArC), 185.9 (2C=O). Anal. Calcd for C28H18N6O2S2 (534.61): C, 62.91; H, 3.39; N, 15.72. Found: C, 62.81; H, 3.32; N, 15.67%.
Method B. To a mixture of diethyl 3,4-dimethylthieno[2,3-b]thiophene-2,5-dicarboxylate (1, 3.12 g, 10 mmol) and 2-(1H-benzo[d]imidazol-2-yl)acetonitrile (3.14 g, 20 mmol) in dry benzene (25 mL) and dimethylformamide (1 mL) was added sodium hydride (0.96 g, 60%). The reaction mixture was refluxed for 4 h, then allowed to cool. The solid that precipitated was collected by filtration, washed with ether and dried. The solid product was dissolved in water and the resulting solution was neutralised to pH 7 with concentrated hydrochloric acid. The precipitated solid was collected by filtration, washed with water and dried. Recrystallisation of the crude product from DMF/water gave a product (60% yield) identical in all respects (TLC, IR spectrum) with that obtained by method A.
Synthesis of (3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis((3-amino-5-(methylthio)-1H-pyrazol-4-yl)methanone) (8). To a solution of compound 3 (0.51 g, 1 mmol) in EtOH (20 mL), hydrazine hydrate (80%, 0.2 mL, 2 mmol) was added and the reaction mixture was refluxed for 4 h, and then left to cool. The solid product so formed was filtered off, washed with EtOH and dried. Recrystallization from DMF/ EtOH afforded 8 in 55% yield; mp 302 °C; IR (KBr) ν max: 3,427, 3,214 and 3,177 (NH, NH2), 1,675 (C=O) cm−1; 1H-NMR (DMSO-d6): δ 2.49 (s, 6H, 2CH3), 2.89 (s, 6H, 2CH3), 5.5 (s, 4H, D2O-exchangeable, 2NH2), 7.95 (s, 2H, D2O-exchangeable, 2NH); 13C-NMR (DMSO-d6): δ 8.3 (2CH3), 11.7 (2CH3-SH), 87.8, 115.3, 142.2, (pyrazole ArC), 130.4, 131.8, 136.3, 140.1, (thienothiophene ArC), 185.9 (2C=O). Anal. Calcd for C18H18N6O2S4(478.63): C, 45.17; H, 3.79; N, 17.56. Found: C, 45.27; H, 3.86; N, 17.51%
Synthesis of 4,4'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(2-thioxo-1,2-dihydropyrimidine-5-carbonitrile) (12). To a mixture of compound 9 (0.41 g, 1 mmol) and thiourea (0.15 g, 2.0 mmol) in ethanol (30 mL), a few drops of piperidine was added and the reaction mixture was refluxed for 8 h, then left to cool to room temperature. The precipitated product was filtered off, washed with EtOH, dried and finally recrystallized from DMF to afford compound 12 in 78% yield; mp. 318 °C; IR (KBr) 3,200 (NH), 2,210 (C≡N), cm−1; 1H-NMR (DMSO-d6): δ 2.49 (s, 6H, 2CH3), 6.37 (s, 2H, 2CH pyrimidine), 11.62 (s, 2H, D2O-exchangeable, 2NH). Anal. Calcd. for C18H10N6S4(438.57): C, 49.29; H, 2.30; N, 19.16. Found: C, 49.20; H, 2.22; N, 19.106%.
Synthesis of 4,4'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(5-benzoyl-2-(phenylamino)- thiophene- 3-carbonitrile) (17). To a stirred solution of potassium hydroxide (0.11 g, 2 mmol) in DMF (20 mL) was added compound 2 (0.30 g, 1 mmol). After stirring for 30 min, phenyl isothiocyanate (0.27 g, 2 mmol) was added to the resulting mixture. Stirring was continued for 6 h, and then 2-bromo-1-phenylethanone (0.40 g, 2 mmol) was added portionwise over a period of 30 min. After the addition was complete, the reaction mixture was stirred for additional 12 h, during which the 2-bromo-1-phenylethanone went into solution and a yellow product precipitated. The solid product was filtered off, washed with EtOH and dried, Recrystallization from EtOH/DMF afforded 17 in 86% yield, mp < 320 °C; IR (KBr) ν max: 3,277 (NH), 2,212 (C≡N), 1618 (C=O) cm−1; 1H-NMR (DMSO-d6): δ 2.07 (s, 6H, 2CH3), 7.09–7.53 (m, 20H, ArH), 10.6 (s, 2H, D2O-exchangeable, 2NH); 13C-NMR(DMSO-d6): δ 8.3 (2CH3), 115.3 (2CN), 116.3, 117.6, 118.9, 125.3, 126.6, 127.9, 129.1, 136.7 (ArC’s), 130.4, 131.8, 138.8, 140.1 (thienothiophene ArC), 111.0, 133.3, 145.8, 156.0 (thiophene ArC), 187.9 (2C=O). MS m/z (%) 774 (M++1, 88.6%), 773 (M+, 100%), 351 (80.6%), 212 (16.2%), 63(30.3%). Anal. Calcd for C44H28N4O2S4 (772.98): C, 68.37; H, 3.65; N, 7.25. Found: C, 68.31; H, 3.69; N, 7.20%.

4. Conclusions

In summary, the reactivity of diethyl 3,4-dimethylthieno[2,3-b]thiophene-2,5-dicarboxylate (1) as a versatile and readily accessible building block for the synthesis of new bis-heterocycles incorporating thieno[2,3-b]thiophene moieties of potential biological and pharmaceutical importance was investigated.

Acknowledgements

Project (Chem/2010/2) was supported by King Saud University, Deanship of Scientific Research, College of Science Research Center.
  • Sample Availability: Samples of compounds 3-17 are available from the authors.

References

  1. Li, J.T.; Sun, M.X.; He, G.Y.; Xu, X.Y. Efficient and green synthesis ofbis(indolyl)methanes catalyzed by ABS in aqueous media under ultrasoundirradiation. Ultrason. Sonochem. 2011, 18, 412–414. [Google Scholar]
  2. Wang, Z.; Zhao, C.; Zhao, D.; Li, C.; Ahang, J.; Wang, H. The preparation of substituted bithiophenyl aldehydes via the ring opening of dithieno[2,3-b:3′,2′-d]thiophene in the presence of n-BuLi. Tetrahedron 2010, 66, 2168–2174. [Google Scholar] [CrossRef]
  3. Diana, P.; Carbone, A.; Barraja, P.; Kelter, G.; Herbert Fiebig, H.; Cirrincione, G. Synthesis and antitumor activity of 2,5-bis(3′-indolyl)-furans and 3,5-bis(3′-indolyl)-isoxazoles, nortopsentin analogues. Bioorg. Med. Chem. 2010, 18, 4524–4529. [Google Scholar] [CrossRef]
  4. Toyota, K.; Okada, K.; Katsuta, H.; Morita, N. Preparations of bis[2-(2-arylethynyl)-3-thienyl]arenes and bis[2-{2-(trimethylsilyl)ethynyl}-3-thienyl]arenes. Tetrahedron 2009, 65, 145–151. [Google Scholar] [CrossRef]
  5. Todd, E.M.; Zimmerman, S.C. Bis-ureidodeazapterin (Bis-DeAP) as a general route tosupramolecularstar polymers. Tetrahedron 2008, 64, 8558–8570. [Google Scholar] [CrossRef]
  6. Diana, P.; Carbone, A.; Barraja, P.; Montalbano, A.; Martorana, A.; Dattolo, G.; Gia, O.; Dalla Via, L.; Cirrincione, G. Synthesis and antitumor properties of 2,5-bis(3′-indolyl)thiophenes: Analogues of marine alkaloid nortopsentin. Bioorg. Med. Chem. Lett. 2007, 17, 2342–2346. [Google Scholar] [CrossRef]
  7. Blanco, G.; Quintela, J.M.; Peinador, C. Efficient one-pot preparation of bis(pyrazino- [2′,3′:4,5]thieno-[3,2-d]pyrimidin-4-yl)benzenes based on an aza–Wittig/mediated annulation strategy. Tetrahedron 2007, 63, 2034–2041. [Google Scholar] [CrossRef]
  8. Promarak, V.; Punkvuang, A.; Jungsuttiwong, S.; Saengsuwan, S.; Sudyoadsuk, T.; Keawin, T. Synthesis, optical, electrochemical, and thermal properties of α,α′-bis(9,9-bis-n-hexylfluorenyl) substituted oligothiophenes. Tetrahedron Lett. 2007, 48, 3661–3665. [Google Scholar] [CrossRef]
  9. Chakrabarti, J.K.; Horsman, L.; Hotten, T.M.; Pullar, I.A.; Tupper, D.E.; Wright, F.C. 4- Piperazinyl-10H-thieno[2,3-b][1,5]benzodiazepines as potential neuroleptics. J. Med. Chem. 1980, 23, 878–884. [Google Scholar] [CrossRef]
  10. Ram, V.J.; Pandey, H. K.; Vlientick, A.J. Thieno[2,3-d]pyrimidines as potential chemotherapeutic agents. II. J. Heterocycl. Chem. 1981, 18, 1277–1280. [Google Scholar]
  11. Jarak, I.; Kralj, M.; Piantanida, I.; Suman, L.; Zinic, M.; Pavelic, K.; Karminski-Zamola, G. Novel cyano- and amidino-substituted derivatives of thieno[2,3-b]- and thieno[3,2-b]thiophene-2-carboxanilides and thieno[3′,2′:4,5]thieno and thieno[2′,3′:4,5] thieno[2,3-c]quinolones: Synthesis, photochemical synthesis, DNA binding, and antitumor evaluation. Bioorg. Med. Chem. 2006, 14, 2859–2868. [Google Scholar] [CrossRef]
  12. Peters, D.; Hornfeldt, A.B.; Gronowitz, S. Synthesis of various 5-substituted uracils. J. Heterocycl. Chem. 1990, 27, 2165–2173. [Google Scholar] [CrossRef]
  13. Kukolja, S.; Draheim, S.E.; Graves, B.J.; Hunden, D.C.; Pfeil, J.L.; Cooper, R.D.G.; Ott, J.L.; Couter, F.T. Orally absorbable cephalosporin antibiotics. 2. Structure-activity studies of bicyclic glycine derivatives of 7-aminodeacetoxycephalosporanic acid. J. Med. Chem. 1985, 28, 1896–1903. [Google Scholar] [CrossRef]
  14. Prugh, J.D.; Hartman, G.D.; Mallorga, P.J.; McKeever, B.M.; Michelson, S.R.; Murcko, M.A.; Schwam, H.; Smith, R.L.; Sondey, J.M.; Springer, J.P.; Surgrue, M.F. New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b] thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides. J. Med Chem. 1991, 34, 1805–1818. [Google Scholar] [CrossRef]
  15. Hartman, G.D.; Ansdale, P.A. Substituted thieno[2,3-b]thiophene-2-sulfonamides as antiglaucoma agents. U.S. Patent 4,806,562, 21 February 1989. [Google Scholar]
  16. Litvinov, V.P. The latest achievements in thienothiophene chemistry. Russ. Chem. Rev. 2005, 74, 217–248. [Google Scholar] [CrossRef]
  17. Gather, M.C.; Heeny, M.; Zhang, W.; Whitehead, K.S.; Bradley, D.D.C.; McCulloch, I.; Campbell, A.J. An alignable fluorene thienothiophene copolymer with deep-blue electrolumen-escent emission at 410 nm. Chem. Commun. 2008, 1079–1081. [Google Scholar]
  18. He, M.; Li, J.; Sorensen, M. L.; Zhang, F.; Hancock, R.R.; Fong, H.H.; Pozdin, V.A.; Smilgies, D.; Malliaras, G.G. Alkylsubstituted thienothiophene semiconducting materials: structureproperty relationships. J. Am. Chem. Soc. 2009, 131, 11930–11938. [Google Scholar]
  19. Mabkhoot, Y.N. Synthesis and Chemical Characterisation of New Bis-Thieno[2,3-b]thiophene Derivatives. Molecules 2010, 15, 3329–3337. [Google Scholar] [CrossRef]
  20. Mabkhoot, Y.N. Synthesis and Analysis of Some Bis-Heterocyclic Compounds Containing Sulphur. Molecules 2009, 14, 1904–1914. [Google Scholar] [CrossRef]
  21. Comel, A.; Kirsch, G. Efficient one pot preparation of variously substituted thieno[2,3-b] thiophene. J. Heterocycl. Chem. 2001, 38, 1167–1171. [Google Scholar] [CrossRef]
  22. Cowper, R.M.; Davidson, L.H. Phenacyl bromide. Org. Synth. Coll. 1943, II, 480. [Google Scholar]

Share and Cite

MDPI and ACS Style

Mabkhot, Y.N.; Abd Elshafy Kheder, N.; Al-Majid, A.M. Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives. Molecules 2010, 15, 9418-9426. https://doi.org/10.3390/molecules15129418

AMA Style

Mabkhot YN, Abd Elshafy Kheder N, Al-Majid AM. Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives. Molecules. 2010; 15(12):9418-9426. https://doi.org/10.3390/molecules15129418

Chicago/Turabian Style

Mabkhot, Yahia Nasser, Nabila Abd Elshafy Kheder, and Abdullah Mohammad Al-Majid. 2010. "Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives" Molecules 15, no. 12: 9418-9426. https://doi.org/10.3390/molecules15129418

APA Style

Mabkhot, Y. N., Abd Elshafy Kheder, N., & Al-Majid, A. M. (2010). Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives. Molecules, 15(12), 9418-9426. https://doi.org/10.3390/molecules15129418

Article Metrics

Back to TopTop