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Molecules 2010, 15(12), 9418-9426; https://doi.org/10.3390/molecules15129418

Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives

1
Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
2
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
Current Address: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia
*
Author to whom correspondence should be addressed.
Received: 12 October 2010 / Revised: 15 December 2010 / Accepted: 16 December 2010 / Published: 20 December 2010
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Abstract

A facile and convenient synthesis of bis(2-(1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile), bis((3-amino-5-(methylthio)-1H-pyrazol-4-yl)methanone) and bis(2-thioxo-1,2-dihydropyrimidine-5-carbonitrile) derivatives incorporating a thieno- [2,3-b]thiophene moiety via versatile, readily accessible diethyl 3,4-dimethylthieno-[2,3-b]thiophene-2,5-dicarboxylate (1) is described.
Keywords: thieno[2,3-b]thiophene; bis-heterocycles; nucleophilic addition; 2-bromo-1-phenylethanone thieno[2,3-b]thiophene; bis-heterocycles; nucleophilic addition; 2-bromo-1-phenylethanone
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Mabkhot, Y.N.; Abd Elshafy Kheder, N.; Al-Majid, A.M. Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives. Molecules 2010, 15, 9418-9426.

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