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Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones

1
Department of Applied Chemistry and Ecology, Faculty of Food Technology, J. J. Strossmayer University, Franje Kuhača 20, 31 000 Osijek, Croatia
2
Department of Biology, J. J. Strossmayer University, Trg Ljudevita Gaja 6, 31 000 Osijek, Croatia
*
Author to whom correspondence should be addressed.
Molecules 2010, 15(10), 6795-6809; https://doi.org/10.3390/molecules15106795
Received: 12 June 2010 / Revised: 21 September 2010 / Accepted: 27 September 2010 / Published: 29 September 2010
A series of Schiff’s bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their antioxidant activity by the phosphomolybdenum method. Most of the Schiff’s bases and thiazolidine-4-ones bearing two hydroxyl groups on the phenyl ring showed excellent antioxidant activity in comparison with ascorbic acid. Preliminary investigation on cytotoxic and antifungal activity was done on some representative samples. View Full-Text
Keywords: coumarin; hydrazides; aromatic Schiffs bases; N-(2-aryl-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide; antioxidant activity; biological activity coumarin; hydrazides; aromatic Schiffs bases; N-(2-aryl-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide; antioxidant activity; biological activity
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MDPI and ACS Style

Čačić, M.; Molnar, M.; Šarkanj, B.; Has-Schön, E.; Rajković, V. Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones. Molecules 2010, 15, 6795-6809. https://doi.org/10.3390/molecules15106795

AMA Style

Čačić M, Molnar M, Šarkanj B, Has-Schön E, Rajković V. Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones. Molecules. 2010; 15(10):6795-6809. https://doi.org/10.3390/molecules15106795

Chicago/Turabian Style

Čačić, Milan, Maja Molnar, Bojan Šarkanj, Elizabeta Has-Schön, and Valentina Rajković. 2010. "Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones" Molecules 15, no. 10: 6795-6809. https://doi.org/10.3390/molecules15106795

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