Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract
by
Saruth Nithitanakool 1, Pimolpan Pithayanukul 1,*, Rapepol Bavovada 2 and Patchreenart Saparpakorn 3
Saruth Nithitanakool 1, Pimolpan Pithayanukul 1,*, Rapepol Bavovada 2 and Patchreenart Saparpakorn 3
1
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
2
Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10300, Thailand
3
Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
*
Author to whom correspondence should be addressed.
Molecules 2009, 14(1), 257-265; https://doi.org/10.3390/molecules14010257
Received: 16 November 2008 / Revised: 18 December 2008 / Accepted: 4 January 2009 / Published: 7 January 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
The alcoholic extract from seed kernels of Thai mango (Mangifera indica L. cv. ‘Fahlun’) (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent, dose-dependent inhibitory effects on tyrosinase with respect to L-DOPA. Molecular docking studies revealed that the binding orientations of the phenolic principles were in the tyrosinase binding pocket and their orientations were located in the hydrophobic binding pocket surrounding the binuclear copper active site. The results indicated a possible mechanism for their anti-tyrosinase activity which may involve an ability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.
View Full-Text
Keywords:
Mangifera indica L; Molecular docking study; Polyphenols; Pentagalloylglucopyranose; Tyrosinase inhibitor
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License
MDPI and ACS Style
Nithitanakool, S.; Pithayanukul, P.; Bavovada, R.; Saparpakorn, P. Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract. Molecules 2009, 14, 257-265.
Show more citation formats
