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Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles

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Department of Chemistry, Faculty of Science, Cairo University, Giza-12613- Egypt
2
Department of Chemistry, Faculty of Science, Kuwait University, Safat 13060 Kuwait
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Author to whom correspondence should be addressed.
Molecules 2008, 13(12), 3140-3148; https://doi.org/10.3390/molecules13123140
Received: 5 September 2008 / Revised: 27 September 2008 / Accepted: 5 November 2008 / Published: 15 December 2008
Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-arylbutanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b. Treatment of the latter with acetonitrile afforded novel β-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the corresponding pyridyl aminopyrazoles 8a,b and pyridyl aminoisoxazoles 10a,b, respectively. View Full-Text
Keywords: β-Oxoalkanonitriles; 3-Pyrazolylamine; 3-Isoxazolylamine; Phenacyl bromide; Ethyl cyanoacetate β-Oxoalkanonitriles; 3-Pyrazolylamine; 3-Isoxazolylamine; Phenacyl bromide; Ethyl cyanoacetate
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Riyadh, S.M.; Al-Matar, H.M.; Elnagdi, M.H. Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles. Molecules 2008, 13, 3140-3148.

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