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Open AccessArticle

An Information Theory Approach for the Analysis of Individual and Combined Evaluation Parameters of Multiple Age-Related Diseases

1
C.D. Technologies Ltd., Beer Sheba 8445914, Israel
2
Department of Science, Technology and Society, Bar Ilan University, Ramat Gan 5290002, Israel
3
The Geriatric Medical Center "Shmuel Harofe”, Beer Yaakov, Affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel
*
Authors to whom correspondence should be addressed.
Entropy 2019, 21(6), 572; https://doi.org/10.3390/e21060572
Received: 3 February 2019 / Revised: 23 May 2019 / Accepted: 4 June 2019 / Published: 5 June 2019
In view of the frequent presence of several aging-related diseases in geriatric patients, there is a need to develop analytical methodologies that would be able to perform diagnostic evaluation of several diseases at once by individual or combined evaluation parameters and select the most informative parameters or parameter combinations. So far there have been no established formal methods to enable such capabilities. We develop a new formal method for the evaluation of multiple age-related diseases by calculating the informative values (normalized mutual information) of particular parameters or parameter combinations on particular diseases, and then combine the ranks of informative values to provide an overall estimation (or correlation) on several diseases at once. Using this methodology, we evaluate a geriatric cohort, with several common age-related diseases, including cognitive and physical impairments (dementia, chronic obstructive pulmonary disease—COPD and ischemic heart disease), utilizing a set of evaluation parameters (such as demographic data and blood biomarkers) routinely available in geriatric clinical practice. This method permitted us to establish the most informative parameters and parameter combinations for several diseases at once. Combinations of evaluation parameters were shown to be more informative than individual parameters. This method, with additional clinical data, may help establish the most informative parameters and parameter combinations for the diagnostic evaluation of multiple age-related diseases and enhance specific assessment for older multi-morbid patients and treatments against old-age multimorbidity. View Full-Text
Keywords: multimorbidity; aging; aging-related diseases; normalized mutual information; information theory multimorbidity; aging; aging-related diseases; normalized mutual information; information theory
MDPI and ACS Style

Blokh, D.; Stambler, I.; Lubart, E.; Mizrahi, E.H. An Information Theory Approach for the Analysis of Individual and Combined Evaluation Parameters of Multiple Age-Related Diseases. Entropy 2019, 21, 572.

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