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12 pages, 2722 KiB

Open AccessArticle

Uniform Cu-Based Metal–Organic Framework Micrometer Cubes with Synergistically Enhanced Photodynamic/Photothermal Properties for Rapid Eradication of Multidrug-Resistant Bacteria

by Xiaomei Wang, Ting Zou, Weiqi Wang, Keqiang Xu and Handong Zhang

Pharmaceutics 2025, 17(8), 1018; https://doi.org/10.3390/pharmaceutics17081018 (registering DOI) - 6 Aug 2025

Abstract

Background/Objectives: The rapid emergence of multidrug-resistant bacterial infections demands innovative non-antibiotic therapeutic strategies. Dual-modal photoresponse therapy integrating photodynamic (PDT) and photothermal (PTT) effects offers a promising rapid antibacterial approach, yet designing single-material systems with synergistic enhancement remains challenging. This study aims to [...] Read more.

Background/Objectives: The rapid emergence of multidrug-resistant bacterial infections demands innovative non-antibiotic therapeutic strategies. Dual-modal photoresponse therapy integrating photodynamic (PDT) and photothermal (PTT) effects offers a promising rapid antibacterial approach, yet designing single-material systems with synergistic enhancement remains challenging. This study aims to develop uniform Cu-based metal–organic framework micrometer cubes (Cu-BN) for efficient PDT/PTT synergy. Methods: Cu-BN cubes were synthesized via a one-step hydrothermal method using Cu(NO₃)₂ and 2-amino-p-benzoic acid. The material’s dual-mode responsiveness to visible light (420 nm) and near-infrared light (808 nm) was characterized through UV–Vis spectroscopy, photothermal profiling, and reactive oxygen species (ROS) generation assays. Antibacterial efficacy against multidrug-resistant Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was quantified via colony counting under dual-light irradiation. Results: Under synergistic 420 + 808 nm irradiation for 15 min, Cu-BN (200 μg/mL) achieved rapid eradication of multidrug-resistant E. coli (99.94%) and S. aureus (99.83%). The material reached 58.6 °C under dual-light exposure, significantly exceeding single-light performance. Photodynamic analysis confirmed a 78.7% singlet oxygen (¹O₂) conversion rate. This enhancement stems from PTT-induced membrane permeabilization accelerating ROS diffusion, while PDT-generated ROS sensitized bacteria to thermal damage. Conclusions: This integrated design enables spatiotemporal PDT/PTT synergy within a single Cu-BN system, establishing a new paradigm for rapid-acting, broad-spectrum non-antibiotic antimicrobials. The work provides critical insights for developing light-responsive biomaterials against drug-resistant infections. Full article

(This article belongs to the Special Issue “The Power of Light” in Biomedical and Pharmaceutics: New Approaches for Photodynamic Purposes)

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10 pages, 6824 KiB

Open AccessFeature PaperArticle

Locomotory Effect of Reversibly Restraining the Pectines of Scorpions

by Douglas D. Gaffin, Sofía E. Gálvez Falcón and Mariëlle H. Hoefnagels

Arthropoda 2025, 3(3), 12; https://doi.org/10.3390/arthropoda3030012 (registering DOI) - 6 Aug 2025

Abstract

Scorpions possess unique, ornate mid-ventral sensory organs called pectines. The pectines are used to process chemo- and mechanosensory information acquired from the ground as the animal walks, and they are implicated in a variety of behaviors including navigation and detection of mates and [...] Read more.

Scorpions possess unique, ornate mid-ventral sensory organs called pectines. The pectines are used to process chemo- and mechanosensory information acquired from the ground as the animal walks, and they are implicated in a variety of behaviors including navigation and detection of mates and prey. Many previous researchers have investigated pecten function by cutting the organs from the animals (full ablation) and comparing their behaviors with those of intact scorpions. This drastic approach is likely to not only cause enormous stress to the ablated animals but also change their behavior. Here, we have developed a method for gently and reversibly impairing the pectines by partially covering them to prevent them from lowering to the ground. Specifically, we fabricated small rectangles of a commercially available lightly adhesive foil tape that we placed across the pectines and secured to the body wall with a thin strip of a more strongly adhesive lab tape. Using a repeated measures design, we monitored the animals’ locomotory activity overnight in small behavioral arenas under three conditions: unmodified (intact) control, pectines restrained, and sham control. We found that scorpions with their pectines restrained had a significant increase in both the distance and duration of movement when compared to unmodified and sham control animals. Our method allows for temporary, reversible compromise of pecten function and should be useful in fully understanding the role of pectines in behavior. Full article

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29 pages, 3400 KiB

Open AccessArticle

Value-Added Service Pricing Strategies Considering Customer Stickiness: A Freemium Perspective

by Xuwang Liu, Biying Zhou, Wei Qi, Zhiwu Li and Junwei Wang

J. Theor. Appl. Electron. Commer. Res. 2025, 20(3), 201; https://doi.org/10.3390/jtaer20030201 (registering DOI) - 6 Aug 2025

Abstract

Freemium, a popular business model in the digital economy, offers a basic product for free while charging for advanced features or value-added services. This pricing strategy enables platforms to attract a broad user base and then monetize through premium offerings. Customer characteristics and [...] Read more.

Freemium, a popular business model in the digital economy, offers a basic product for free while charging for advanced features or value-added services. This pricing strategy enables platforms to attract a broad user base and then monetize through premium offerings. Customer characteristics and service price are important factors affecting customer choice behavior in such a model. Based on consumption stickiness, we consider a monopoly that provides value-added services by incorporating a multinomial logit model into a two-stage dynamic pricing model. First, we analyze the optimal pricing of value-added services under a normal sales scenario. We then consider optimal pricing during the marketing period under two strategies—level improvement for value-added services and quality reduction for a basic product—and analyze the applicability of each. The results show that increasing the value-added service level has a positive effect on the optimal price of value-added services, whereas reducing the basic product quality has no effect on the optimal price. Furthermore, the numerical simulation shows that when the depth of consumer stickiness is low, the optimal marketing strategy reduces the quality of the basic product, the price of value-added services should be higher than that in the normal sales period but lower than the price under the level-improvement strategy for value-added services; otherwise, improving the level of the value-added services becomes the optimal approach. This study provides a theoretical basis and decision support for product quality design and service pricing that applies to freemium platforms. Full article

(This article belongs to the Topic Digital Marketing Dynamics: From Browsing to Buying)

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33 pages, 5098 KiB

Open AccessReview

Medicinal Plants for Skin Disorders: Phytochemistry and Pharmacological Insights

by Nazerke Bolatkyzy, Daniil Shepilov, Rakhymzhan Turmanov, Dmitriy Berillo, Tursunay Vassilina, Nailya Ibragimova, Gulzat Berganayeva and Moldyr Dyusebaeva

Molecules 2025, 30(15), 3281; https://doi.org/10.3390/molecules30153281 (registering DOI) - 6 Aug 2025

Abstract

Skin disorders are common and often chronic conditions with significant therapeutic challenges. Limitations of conventional treatments, such as adverse effects and antimicrobial resistance, have increased interest in plant-based alternatives. This article presents the phytochemical composition and pharmacological potential of several medicinal plants traditionally [...] Read more.

Skin disorders are common and often chronic conditions with significant therapeutic challenges. Limitations of conventional treatments, such as adverse effects and antimicrobial resistance, have increased interest in plant-based alternatives. This article presents the phytochemical composition and pharmacological potential of several medicinal plants traditionally used in the treatment of skin diseases, including Rubus vulgaris, Plantago major, Artemisia terrae-albae, and Eryngium planum. Based on an analysis of scientific literature, the presence of bioactive compounds—including flavonoids, anthocyanins, phenolic acids, tannins, and sesquiterpenes—is summarized, along with their antioxidant, anti-inflammatory, and antimicrobial effects. Emphasis is placed on the correlation between traditional ethnomedicinal applications and pharmacological mechanisms. The findings support the potential of these species as sources for dermatological phytotherapeutics. Further research is needed to standardize active constituents, assess safety, and conduct clinical validation. Full article

(This article belongs to the Special Issue Bioactive Molecules in Medicinal Plants)

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21 pages, 1112 KiB

Open AccessArticle

Evaluative Grammar and Non-Standard Comparatives: A Cross-Linguistic Analysis of Ukrainian and English

by Oksana Kovtun

Languages 2025, 10(8), 191; https://doi.org/10.3390/languages10080191 (registering DOI) - 6 Aug 2025

Abstract

This study examines non-standard comparative and superlative adjective forms in Ukrainian and English, emphasizing their evaluative meanings and grammatical deviations. While prescriptive grammar dictates conventional comparison patterns, modern discourse—particularly in advertising, informal communication, and literary texts—exhibits an increasing prevalence of innovative comparative structures. [...] Read more.

This study examines non-standard comparative and superlative adjective forms in Ukrainian and English, emphasizing their evaluative meanings and grammatical deviations. While prescriptive grammar dictates conventional comparison patterns, modern discourse—particularly in advertising, informal communication, and literary texts—exhibits an increasing prevalence of innovative comparative structures. Using a corpus-based approach, this research identifies patterns of positive and negative evaluative meanings, revealing that positive evaluations dominate non-standard comparatives in both languages, particularly in advertising (English: 78.5%, Ukrainian: 80.2%). However, English exhibits a higher tolerance for grammatical flexibility, while Ukrainian maintains a more restricted use, primarily in commercial and expressive discourse. The findings highlight the pragmatic and evaluative functions of such constructions, including hyperbolic emphasis, rhetorical contrast, and branding strategies. These insights contribute to research on comparative grammar, sentiment analysis, and natural language processing, particularly in modeling evaluative structures in computational linguistics. Full article

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20 pages, 7016 KiB

Open AccessArticle

Design, Analysis and Control of Tracked Mobile Robot with Passive Suspension on Rugged Terrain

by Junfeng Gao, Yi Li, Jingfu Jin, Zhicheng Jia and Chao Wei

Actuators 2025, 14(8), 389; https://doi.org/10.3390/act14080389 (registering DOI) - 6 Aug 2025

Abstract

With the application of tracked mobile robots in detection and rescue, how to improve their stability and trafficability has become the research focus. In order to improve the driving ability and trafficability of tracked mobile robots in rugged terrain, this paper proposes a [...] Read more.

With the application of tracked mobile robots in detection and rescue, how to improve their stability and trafficability has become the research focus. In order to improve the driving ability and trafficability of tracked mobile robots in rugged terrain, this paper proposes a new type of tracked mobile robot using passive suspension. By adding a connecting rod differential mechanism between the left and right track mechanisms, the contact stability between the track and terrain is enhanced. The kinematics model and attitude relationship of the suspension are analyzed and established, and the rationality of the passive suspension scheme is verified by dynamic simulation. The simulation results show that the tracked robot with passive suspension shows good obstacle surmounting performance, but there will be a heading deflection problem. Therefore, a track drive speed of the driving state compensation control is proposed based on the driving scene, which can effectively solve the problem of slip and heading deflection. Through the field test of the robot prototype, the effectiveness of the suspension scheme and control system is verified, which provides a useful reference for the scheme design and performance improvement of the tracked mobile robot in complex field scenes. Full article

(This article belongs to the Section Actuators for Robotics)

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25 pages, 6821 KiB

Open AccessArticle

Hierarchical Text-Guided Refinement Network for Multimodal Sentiment Analysis

by Yue Su and Xuying Zhao

Entropy 2025, 27(8), 834; https://doi.org/10.3390/e27080834 (registering DOI) - 6 Aug 2025

Abstract

Multimodal sentiment analysis (MSA) benefits from integrating diverse modalities (e.g., text, video, and audio). However, challenges remain in effectively aligning non-text features and mitigating redundant information, which may limit potential performance improvements. To address these challenges, we propose a Hierarchical Text-Guided Refinement Network [...] Read more.

Multimodal sentiment analysis (MSA) benefits from integrating diverse modalities (e.g., text, video, and audio). However, challenges remain in effectively aligning non-text features and mitigating redundant information, which may limit potential performance improvements. To address these challenges, we propose a Hierarchical Text-Guided Refinement Network (HTRN), a novel framework that refines and aligns non-text modalities using hierarchical textual representations. We introduce Shuffle-Insert Fusion (SIF) and the Text-Guided Alignment Layer (TAL) to enhance crossmodal interactions and suppress irrelevant signals. In SIF, empty tokens are inserted at fixed intervals in unimodal feature sequences, disrupting local correlations and promoting more generalized representations with improved feature diversity. The TAL guides the refinement of audio and visual representations by leveraging textual semantics and dynamically adjusting their contributions through learnable gating factors, ensuring that non-text modalities remain semantically coherent while retaining essential crossmodal interactions. Experiments demonstrate that the HTRN achieves state-of-the-art performance with accuracies of 86.3% (Acc-2) on CMU-MOSI, 86.7% (Acc-2) on CMU-MOSEI, and 80.3% (Acc-2) on CH-SIMS, outperforming existing methods by 0.8–3.45%. Ablation studies validate the contributions of SIF and the TAL, showing 1.9–2.1% performance gains over baselines. By integrating these components, the HTRN establishes a robust multimodal representation learning framework. Full article

(This article belongs to the Section Information Theory, Probability and Statistics)

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10 pages, 1248 KiB

Open AccessBrief Report

From Nest to Nest: High-Precision GPS-GSM Tracking Reveals Full Natal Dispersal Process in a First-Year Female Montagu’s Harrier Circus pygargus

by Giampiero Sammuri, Guido Alari Esposito, Marta De Paulis, Francesco Pezzo, Andrea Sforzi and Flavio Monti

Birds 2025, 6(3), 40; https://doi.org/10.3390/birds6030040 (registering DOI) - 6 Aug 2025

Abstract

This report presents the first complete natal dispersal trajectory of a female Montagu’s Harrier Circus pygargus, tracked in real time from fledging to first breeding using high-resolution continuous Global Positioning System (GPS) telemetry. The bird’s first flight occurred on 26 July 2024, [...] Read more.

This report presents the first complete natal dispersal trajectory of a female Montagu’s Harrier Circus pygargus, tracked in real time from fledging to first breeding using high-resolution continuous Global Positioning System (GPS) telemetry. The bird’s first flight occurred on 26 July 2024, initiating a 31-day post-fledging dependence phase (PFDP), followed by a 23-day pre-migratory phase (PMP), during which it explored areas up to 280.8 km from the nest and eventually settled ca. 190 km away in the Sirente-Velino Regional Park. From there, autumn migration began on 18 September 2024. The bird reached its first wintering site in Mali by 15 October. It used four wintering areas over 178 days, with a winter home range of 37,615.02 km². Spring migration started on 11 April 2025 and lasted 21 days, ending with arrival in the Gran Sasso e Monti della Laga National Park (Central Italy) on 2 May. The bird used two main sites during the pre-breeding phase (PRBP) before laying eggs on 2 June 2025. The natal dispersal distance, from birthplace to nest site, was 151.28 km. Over 311 days, it covered a total of 14,522.23 km. These findings highlight the value of advanced telemetry in revealing early-life movement ecology and are useful for understanding species-specific patterns of survival, reproduction, and space use and can inform conservation actions. Full article

(This article belongs to the Special Issue Unveiling the Breeding Biology and Life History Evolution in Birds)

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35 pages, 8516 KiB

Open AccessArticle

Study on Stress Monitoring and Risk Early Warning of Flexible Mattress Deployment in Deep-Water Sharp Bend Reaches

by Chu Zhang, Ping Li, Zebang Cui, Kai Wu, Tianyu Chen, Zhenjia Tian, Jianxin Hao and Sudong Xu

Water 2025, 17(15), 2333; https://doi.org/10.3390/w17152333 (registering DOI) - 6 Aug 2025

Abstract

This study addresses the complex challenges associated with flexible mattress (soft mattress) installation in the sharply curved and deep-water sections of the Yangtze River, particularly in the Yaozui revetment reconstruction project. Under extreme hydrodynamic conditions—water depths exceeding 30 m and velocities over 2.5 [...] Read more.

This study addresses the complex challenges associated with flexible mattress (soft mattress) installation in the sharply curved and deep-water sections of the Yangtze River, particularly in the Yaozui revetment reconstruction project. Under extreme hydrodynamic conditions—water depths exceeding 30 m and velocities over 2.5 m/s—the risk of structural failures such as displacement, flipping, or tearing of the mattress becomes significant. To improve construction safety and stability, the study integrates numerical modeling and on-site strain monitoring to analyze the mechanical response of flexible mattresses during deployment. A three-dimensional finite element model based on the catenary theory was developed to simulate stress distributions under varying flow velocities and angles, revealing stress concentrations at the mattress’s upper edge and reinforcement junctions. Concurrently, a real-time monitoring system using high-precision strain sensors was deployed on critical shipboard components, with collected data analyzed through a remote IoT platform. The results demonstrate strong correlations between mattress strain, flow velocity, and water depth, enabling the identification of high-risk operational thresholds. The proposed monitoring and early-warning framework offers a practical solution for managing construction risks in extreme riverine environments and contributes to the advancement of intelligent construction management for underwater revetment works. Full article

(This article belongs to the Section Oceans and Coastal Zones)

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23 pages, 6490 KiB

Open AccessArticle

LISA-YOLO: A Symmetry-Guided Lightweight Small Object Detection Framework for Thyroid Ultrasound Images

by Guoqing Fu, Guanghua Gu, Wen Liu and Hao Fu

Symmetry 2025, 17(8), 1249; https://doi.org/10.3390/sym17081249 (registering DOI) - 6 Aug 2025

Abstract

Non-invasive ultrasound diagnosis, combined with deep learning, is frequently used for detecting thyroid diseases. However, real-time detection on portable devices faces limitations due to constrained computational resources, and existing models often lack sufficient capability for small object detection of thyroid nodules. To address [...] Read more.

Non-invasive ultrasound diagnosis, combined with deep learning, is frequently used for detecting thyroid diseases. However, real-time detection on portable devices faces limitations due to constrained computational resources, and existing models often lack sufficient capability for small object detection of thyroid nodules. To address this, this paper proposes an improved lightweight small object detection network framework called LISA-YOLO, which enhances the lightweight multi-scale collaborative fusion algorithm. The proposed framework exploits the inherent symmetrical characteristics of ultrasound images and the symmetrical architecture of the detection network to better capture and represent features of thyroid nodules. Specifically, an improved depthwise separable convolution algorithm replaces traditional convolution to construct a lightweight network (DG-FNet). Through symmetrical cross-scale fusion operations via FPN, detection accuracy is maintained while reducing computational overhead. Additionally, an improved bidirectional feature network (IMS F-NET) fully integrates the semantic and detailed information of high- and low-level features symmetrically, enhancing the representation capability for multi-scale features and improving the accuracy of small object detection. Finally, a collaborative attention mechanism (SAF-NET) uses a dual-channel and spatial attention mechanism to adaptively calibrate channel and spatial weights in a symmetric manner, effectively suppressing background noise and enabling the model to focus on small target areas in thyroid ultrasound images. Extensive experiments on two image datasets demonstrate that the proposed method achieves improvements of 2.3% in F1 score, 4.5% in mAP, and 9.0% in FPS, while maintaining only 2.6 M parameters and reducing GFLOPs from 6.1 to 5.8. The proposed framework provides significant advancements in lightweight real-time detection and demonstrates the important role of symmetry in enhancing the performance of ultrasound-based thyroid diagnosis. Full article

(This article belongs to the Section Computer)

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26 pages, 3194 KiB

Open AccessArticle

Evolution Trends, Spatial Differentiation, and Convergence Characteristics of Urban Ecological Economic Resilience in China

by Xiaofeng Ran, Rui Ding and Bowen Zhang

Systems 2025, 13(8), 666; https://doi.org/10.3390/systems13080666 (registering DOI) - 6 Aug 2025

Abstract

Achieving a win-win situation for both economy and ecology is crucial for promoting sustainable social development and shaping new advantages in high-quality developments. This article constructs an ecological economic resilience (EER) analysis framework by integrating both ecological and economic dimensions from a resilience [...] Read more.

Achieving a win-win situation for both economy and ecology is crucial for promoting sustainable social development and shaping new advantages in high-quality developments. This article constructs an ecological economic resilience (EER) analysis framework by integrating both ecological and economic dimensions from a resilience perspective. Based on panel data from 290 cities in China, it explores the dynamic evolution characteristics, regional differences, and convergence trends of EER. The findings indicate that the EER has weakened nationwide and in the four major economic regions, overall tending towards stability. Significant disparities exist in EER, particularly pronounced in the northeast. There is

σ

convergence in the nation as well as in the northeast and east regions. Additionally, both absolute and conditional

β

convergence is evident nationwide and in all regions, with conditional convergence occurring at a faster pace. The research findings in this paper provide solid theoretical support for promoting regional coordinated development and constructing a new development paradigm. Full article

(This article belongs to the Special Issue Complex Systems Theory in Regional and Urban Marketing: Strategies for Resilient, Sustainable, and Smart Cities)

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14 pages, 1614 KiB

Open AccessArticle

Adverse Pathology After Radical Prostatectomy in Low- and Intermediate-Risk Prostate Cancer: A Propensity Score-Matched Analysis of Long-Term Health-Related Quality of Life

by Michael Chaloupka, Alexander Buchner, Marc Kidess, Benedikt Ebner, Yannic Volz, Nikolaos Pyrgidis, Stephan Timo Ledderose, Dirk-André Clevert, Julian Marcon, Philipp Weinhold, Christian G. Stief and Maria Apfelbeck

Diagnostics 2025, 15(15), 1969; https://doi.org/10.3390/diagnostics15151969 (registering DOI) - 6 Aug 2025

Abstract

Background and Objective: Adverse pathology to high-risk prostate cancer (PCa) after radical prostatectomy (upgrading) poses a threat to risk stratification and treatment planning. The impact on sexual function, urinary continence, and health-related quality of life (HRQOL) remains unclear. Methods: From 2004 [...] Read more.

Background and Objective: Adverse pathology to high-risk prostate cancer (PCa) after radical prostatectomy (upgrading) poses a threat to risk stratification and treatment planning. The impact on sexual function, urinary continence, and health-related quality of life (HRQOL) remains unclear. Methods: From 2004 to 2024, 4189 patients with preop low-/intermediate-risk PCa (Gleason score 6 or 7a, PSA ≤ 20 ng/mL) underwent radical prostatectomy at our department and were analyzed. Primary endpoint was HRQOL, erectile function, and urinary continence. Secondary endpoint was rate of salvage therapies and biochemical-free survival. Propensity score matching was performed using “operative time”, “robot-assisted surgery”, “blood loss”, “nerve-sparing surgery”, “age”, and “BMI” to represent comparable surgical approach. Median follow-up was 39 months (Interquartile-range (IQR) 15–60). Key Findings and Limitations: Patients who were upgraded to high-risk PCa showed a higher rate of postoperative radiotherapy and androgen-deprivation therapy compared to patients who were not upgraded (21% vs. 7%, p < 0.001; 9% vs. 3%, p = 0.002). Five-year biochemical recurrence-free survival was 68% in the upgrading group vs. 84% in the no-upgrading group (p < 0.001). We saw no difference in patient-reported HRQOL, urinary continence, or erectile function. Multivariable analysis showed that postoperative upgrading was a significant risk for not achieving good overall HRQOL (OR: 0.77, 95% CI: 0.61–0.97, p = 0.028) during the follow-up. Conclusions and Clinical Implications: Although postoperative upgrading to high-risk PCa leads to worse oncologic outcomes and higher salvage therapy rates, this study indicates that its impact on health-related quality of life is minimal and should not deter a cautious approach to radical prostatectomy. Full article

(This article belongs to the Section Clinical Diagnosis and Prognosis)

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12 pages, 754 KiB

Open AccessArticle

High Efficacy of Triclabendazole/Ivermectin Combination Compared to Triclabendazole Monotherapy for Treating Human Fascioliasis in Upper Egypt: A Prospective Study

by Waleed Attia Hassan, Haidi Karam-Allah Ramadan, Mona Gaber, Samia S. Alkhalil and Alzahraa Abdelraouf Ahmad

Trop. Med. Infect. Dis. 2025, 10(8), 221; https://doi.org/10.3390/tropicalmed10080221 (registering DOI) - 6 Aug 2025

Abstract

Triclabendazole (TCBZ) is the gold standard treatment for fascioliasis. However, reports on resistance are increasing, emphasizing the need for alternative therapy. Combining TCBZ with ivermectin (IVM) was found to be effective for treating animal fascioliasis. Building on this, we aimed to evaluate the [...] Read more.

Triclabendazole (TCBZ) is the gold standard treatment for fascioliasis. However, reports on resistance are increasing, emphasizing the need for alternative therapy. Combining TCBZ with ivermectin (IVM) was found to be effective for treating animal fascioliasis. Building on this, we aimed to evaluate the efficacy of the TCBZ/IVM combination therapy for human fascioliasis. This study enrolled 136 patients with Fasciola from Upper Egypt, and they were divided into the first group (n = 65), who received TCBZ monotherapy, and the second group (n = 71), who received the TCBZ/IVM combination. Assessments were to evaluate treatment response based on clinical, eosinophilic, and radiological parameters. Chronic fasciolosis was diagnosed in 17 patients (12.5%). No differences were observed in age and sex. Significant improvements were noted in all parameters in both groups, with more pronounced effects observed in the second group. A significantly higher complete response, including clinical, eosinophilic, and radiological improvements, was reported in the combined therapy group, with 53.3% compared to 26.2% in the monotherapy group (p < 0.001). A high baseline eosinophilic count was significantly associated with response. The efficacy of the TCBZ/IVM combination for treating human fascioliasis suggested a possible boosting effect, which can benefit regions of TCBZ failure. Further large-scale randomized studies are warranted to confirm these findings. Full article

(This article belongs to the Section Neglected and Emerging Tropical Diseases)

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22 pages, 322 KiB

Open AccessArticle

The Impact of Green Finance on Energy Transition Under Climate Change

by Zhengwei Ma and Xiangli Jiang

Sustainability 2025, 17(15), 7112; https://doi.org/10.3390/su17157112 (registering DOI) - 6 Aug 2025

Abstract

In recent years, growing concerns over environmental degradation and deepening awareness of the necessity of sustainable development have propelled green and low-carbon energy transition into a focal issue for both academia and policymakers. By decomposing energy transition into the transformation of energy structure [...] Read more.

In recent years, growing concerns over environmental degradation and deepening awareness of the necessity of sustainable development have propelled green and low-carbon energy transition into a focal issue for both academia and policymakers. By decomposing energy transition into the transformation of energy structure and the upgrading of energy efficiency, this study investigates the impact and mechanisms of green finance on energy transition across 30 provinces (municipalities and autonomous regions) in China, with the exception of Tibet. In addition, the impact of climate change is incorporated into the analytical framework. Empirical results demonstrate that green finance development significantly accelerates energy transition, a conclusion robust to rigorous validation. Analysis of the mechanism shows that green finance promotes energy transition through the facilitation of technological innovation and the upgrade of industrial structures. Moreover, empirical evidence reveals that climate change undermines the promotional influence of sustainable finance on energy system transformation. The magnitude of this suppression varies nonlinearly across provincial jurisdictions with differing energy transition progress. Regional heterogeneity analyses further uncover marked discrepancies in climate–finance interactions, demonstrating amplified effects in coastal economic hubs, underdeveloped western provinces, and regions with mature eco-financial markets. According to these findings, actionable policy suggestions are put forward to strengthen green finance and accelerate energy transition. Full article

(This article belongs to the Special Issue Analysis of Energy Systems from the Perspective of Sustainability)

14 pages, 1958 KiB

Open AccessArticle

In Situ Response Time Measurement of RTD Based on LCSR Method

by Yanyong Song, Yi Liang, Zhenwen Zhang, Geyi Su and Mingxu Su

Sensors 2025, 25(15), 4826; https://doi.org/10.3390/s25154826 (registering DOI) - 6 Aug 2025

Abstract

This study aims to overcome the limitations of conventional plunge tests for evaluating resistance temperature detector (RTD) response times under actual operating conditions, particularly in confined nuclear power plant piping. An in situ measurement device based on the loop current step response (LCSR) [...] Read more.

This study aims to overcome the limitations of conventional plunge tests for evaluating resistance temperature detector (RTD) response times under actual operating conditions, particularly in confined nuclear power plant piping. An in situ measurement device based on the loop current step response (LCSR) method was developed, with a conversion relationship to plunge test results established through numerical simulation and experimental validation. Investigations in a rotating water channel (over the flow velocity range of 0.2 to 0.6) confirmed excellent agreement in RTD response time, showing only 3.78% deviation between second-order-converted LCSR and plunge test measurements at 0.6 m/s. Both methods consistently revealed reduced RTD response times at higher flow velocities, with deviations consistently within ±10%, complying with nuclear instrumentation standards (NB/T 20069-2012). The LCSR method enables reliable in situ assessment while maintaining strong correlation with laboratory plunge tests. Full article

(This article belongs to the Section Electronic Sensors)

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15 pages, 2415 KiB

Open AccessArticle

HBiLD-IDS: An Efficient Hybrid BiLSTM-DNN Model for Real-Time Intrusion Detection in IoMT Networks

by Hamed Benahmed, Mohammed M’hamedi, Mohammed Merzoug, Mourad Hadjila, Amina Bekkouche, Abdelhak Etchiali and Saïd Mahmoudi

Information 2025, 16(8), 669; https://doi.org/10.3390/info16080669 (registering DOI) - 6 Aug 2025

Abstract

The Internet of Medical Things (IoMT) is revolutionizing healthcare by enabling continuous patient monitoring, early diagnosis, and personalized treatments. However, the het-erogeneity of IoMT devices and the lack of standardized protocols introduce serious security vulnerabilities. To address these challenges, we propose a hybrid [...] Read more.

The Internet of Medical Things (IoMT) is revolutionizing healthcare by enabling continuous patient monitoring, early diagnosis, and personalized treatments. However, the het-erogeneity of IoMT devices and the lack of standardized protocols introduce serious security vulnerabilities. To address these challenges, we propose a hybrid BiLSTM-DNN intrusion detection system, named HBiLD-IDS, that combines Bidirectional Long Short-Term Memory (BiLSTM) networks with Deep Neural Networks (DNNs), leveraging both temporal dependencies in network traffic and hierarchical feature extraction. The model is trained and evaluated on the CICIoMT2024 dataset, which accurately reflects the diversity of devices and attack vectors encountered in connected healthcare environments. The dataset undergoes rigorous preprocessing, including data cleaning, feature selection through correlation analysis and recursive elimination, and feature normalization. Compared to existing IDS models, our approach significantly enhances detection accuracy and generalization capacity in the face of complex and evolving attack patterns. Experimental results show that the proposed IDS model achieves a classification accuracy of 98.81% across 19 attack types confirming its robustness and scalability. This approach represents a promising solution for strengthening the security posture of IoMT networks against emerging cyber threats. Full article

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27 pages, 315 KiB

Open AccessArticle

Belonging Among Black Women DEI Leaders Post the 2020 Social Justice Movement

by Naima Hall and Jennifer M. Johnson

Educ. Sci. 2025, 15(8), 1002; https://doi.org/10.3390/educsci15081002 (registering DOI) - 6 Aug 2025

Abstract

This convergent mixed-methods study explores the lived experiences of Black women DEI leaders at predominantly white institutions within the context of an increasingly contentious national discourse surrounding diversity, equity, and inclusion (DEI) in higher education. Conducted prior to the 2024 election, a period [...] Read more.

This convergent mixed-methods study explores the lived experiences of Black women DEI leaders at predominantly white institutions within the context of an increasingly contentious national discourse surrounding diversity, equity, and inclusion (DEI) in higher education. Conducted prior to the 2024 election, a period marked by escalating resistance to DEI efforts, this research explores how America’s racial reckoning influenced institutional DEI initiatives and shaped the realities of those leading this work. Data were collected through a climate survey of 20 DEI administrators and semi-structured interviews with three senior-level Black women DEI leaders. The survey findings suggest that institutional commitments to DEI were largely reactive, emerging as crisis responses to national calls for racial justice. These efforts resulted in the short-term elevation of Black women into leadership roles, often without sustained structural support. The interview data revealed that Black women senior DEI leaders routinely encounter discrimination, marginalization, and the paradox of hypervisibility and invisibility within their roles. This study concludes with implications and suggestions for institutional policy and structural reform aimed at fostering more equitable and sustainable DEI leadership environments. Full article

(This article belongs to the Special Issue Navigating the Challenges, Tensions, and Complexities of Political and Legislative Attacks in Higher Education)

17 pages, 265 KiB

Open AccessArticle

Who I Am, and Why That Matters

by Louise Rak, Elsie Randall, Meaghan Katrak-Harris and Tamara Blakemore

Youth 2025, 5(3), 83; https://doi.org/10.3390/youth5030083 (registering DOI) - 6 Aug 2025

Abstract

Where we find and form identity and belonging, meaning and purpose, is often entangled in the dynamics that play out between people and place, and for Aboriginal and Torres Strait Islander Peoples, the legacy and ongoing experience of invasion and colonisation. Place-based understandings [...] Read more.

Where we find and form identity and belonging, meaning and purpose, is often entangled in the dynamics that play out between people and place, and for Aboriginal and Torres Strait Islander Peoples, the legacy and ongoing experience of invasion and colonisation. Place-based understandings of identity and its importance in shaping young people’s experience of what is possible and probable in their futures might be critical to framing cross-cultural work with young people impacted by violence and trauma. This paper draws on practitioner reflections of work with young Aboriginal women both on, and off Country, highlighting common and distinct themes related to identity formation and migration in navigating new futures. These include connection to Country and spiritual connection, family and kinship relationships, Women’s Business and felt cultural safety. The findings illustrate a meaningful parallel instructive to practice; for both young women and practitioners, access to cultural knowledge and connection is strengthened by endorsement and in turn strengthens understanding and experienced safety. This work emphasises the importance of creating culturally connected opportunities, sensitive to dynamics of place, to support positive identity expression and wellbeing. Full article

(This article belongs to the Special Issue Supporting Youth: Strengthening Cultural Identity and Promoting Social Justice)

22 pages, 2029 KiB

Open AccessArticle

Regulatory Effects of Endometriosis-Associated Genetic Variants: A Multi-Tissue eQTL Analysis

by Asbiel Felipe Garibaldi-Ríos, Perla Graciela Rodríguez-Gutiérrez, Jesús Magdiel García-Díaz, Guillermo Moisés Zúñiga-González, Luis E. Figuera, Belinda Claudia Gómez-Meda, Ana María Puebla-Pérez, Ingrid Patricia Dávalos-Rodríguez, Blanca Miriam Torres-Mendoza, Itzae Adonai Gutiérrez-Hurtado and Martha Patricia Gallegos-Arreola

Diseases 2025, 13(8), 248; https://doi.org/10.3390/diseases13080248 (registering DOI) - 6 Aug 2025

Abstract

Backgroud. Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by the ectopic presence of endometrial-like tissue. Although genome-wide association studies (GWAS) have identified susceptibility variants, their tissue-specific regulatory impact remains poorly understood. Objective. To functionally characterize endometriosis-associated variants by exploring their regulatory effects [...] Read more.

Backgroud. Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by the ectopic presence of endometrial-like tissue. Although genome-wide association studies (GWAS) have identified susceptibility variants, their tissue-specific regulatory impact remains poorly understood. Objective. To functionally characterize endometriosis-associated variants by exploring their regulatory effects as expression quantitative trait loci (eQTLs) across six physiologically relevant tissues: peripheral blood, sigmoid colon, ileum, ovary, uterus, and vagina. Methods. GWAS-identified variants were cross-referenced with tissue-specific eQTL data from the GTEx v8 database. We prioritized genes either frequently regulated by eQTLs or showing the strongest regulatory effects (based on slope values, which indicate the direction and magnitude of the effect on gene expression). Functional interpretation was performed using MSigDB Hallmark gene sets and Cancer Hallmarks gene collections. Results. A tissue specificity was observed in the regulatory profiles of eQTL-associated genes. In the colon, ileum, and peripheral blood, immune and epithelial signaling genes predominated. In contrast, reproductive tissues showed the enrichment of genes involved in hormonal response, tissue remodeling, and adhesion. Key regulators such as MICB, CLDN23, and GATA4 were consistently linked to hallmark pathways, including immune evasion, angiogenesis, and proliferative signaling. Notably, a substantial subset of regulated genes was not associated with any known pathway, indicating potential novel regulatory mechanisms. Conclusions. This integrative approach highlights the com-plexity of tissue-specific gene regulation mediated by endometriosis-associated variants. Our findings provide a functional framework to prioritize candidate genes and support new mechanistic hypotheses for the molecular pathophysiology of endometriosis. Full article

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13 pages, 504 KiB

Open AccessArticle

Fear of Falling After Total Knee Replacement: A Saudi Experience

by Turki Aljuhani, Jayachandran Vetrayan, Mohammed A. Alfayez, Saleh A. Alshehri, Mohmad H. Alsabani, Lafi H. Olayan, Fahdah A. Aljamaan and Abdulaziz O. Alharbi

Clin. Pract. 2025, 15(8), 146; https://doi.org/10.3390/clinpract15080146 (registering DOI) - 6 Aug 2025

Abstract

Background: Fear of falling (FOF) is a significant concern among older adults, especially after total knee arthroplasty (TKA). FOF can limit daily activities, reduce quality of life, and hinder recovery. This study aimed to investigate the prevalence, severity, and impacts of FOF [...] Read more.

Background: Fear of falling (FOF) is a significant concern among older adults, especially after total knee arthroplasty (TKA). FOF can limit daily activities, reduce quality of life, and hinder recovery. This study aimed to investigate the prevalence, severity, and impacts of FOF in patients undergoing TKA and identify factors contributing to increased FOF. Methods: A prospective observational study was conducted at King Abdulaziz Medical City in Riyadh, Saudi Arabia, from April 2024 to December 2024. This study included 52 participants aged 20 to 75 years who had undergone primary TKA. Data were collected at two time points: after TKA and at three months post-surgery. The Short Falls Efficacy Scale-International (SFES-I) was used to assess the severity of FOF, and the Short Form 36 (SF-36) was used to measure the quality of life. Descriptive statistics, t-tests, and logistic regression were used for analysis. Results: This study included 52 participants (mean age: 63.77 ± 6.65 years; 82.7% female). Post-TKA, all participants exhibited high FOF (mean SFES-I score: 56.75 ± 8.30). After three months, the mean SFES-I score decreased significantly to 49.04 ± 12.45 (t = 4.408, p < 0.05). Post-TKA, SF-36 showed significant improvements in the physical function, role of physical limitations, bodily pain, vitality, social function, role of emotional limitations, and mental health subdomains. Bilateral total knee arthroplasty, body mass index, and some SF-36 subcomponents—such as general health, vitality, and role of emotional limitations—were identified as factors leading to increased FOF. Conclusions: FOF remains prevalent and severe in TKA patients, even at three months post-surgery, affecting rehabilitation outcomes. Early identification and tailored interventions for FOF should be considered essential components of comprehensive TKA recovery programs. Full article

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17 pages, 326 KiB

Open AccessArticle

Remittances and FDI: Drivers of Employment in the Economic Community of West African States

by Grace Toyin Adigun, Abiola John Asaleye, Olayinka Omolara Adenikinju, Kehinde Damilola Ilesanmi, Sunday Festus Olasupo and Adedoyin Isola Lawal

J. Risk Financial Manag. 2025, 18(8), 436; https://doi.org/10.3390/jrfm18080436 (registering DOI) - 6 Aug 2025

Abstract

Unemployment and weak economic productivity are significant global issues, particularly in West Africa. Recently, through diverse mechanisms, remittances and foreign direct investment (FDI) have been sources of foreign capital flow that have positively influenced many less developed economies, including ECOWAS (ECOWAS stands for [...] Read more.

Unemployment and weak economic productivity are significant global issues, particularly in West Africa. Recently, through diverse mechanisms, remittances and foreign direct investment (FDI) have been sources of foreign capital flow that have positively influenced many less developed economies, including ECOWAS (ECOWAS stands for Economic Community of West African States). Nevertheless, these financial flows have exhibited significant inconsistencies, primarily resulting from economic downturns in migrants’ destination countries, with remarkable implications for beneficiary economies. This study, therefore, examines the effect of remittances and FDI on employment in ECOWAS. Specifically, the study assesses the effects of the inflow of remittances and FDI on employment using panel dynamic ordinary least squares (PDOLS) and also investigates the shock effects of remittances and FDI by employing Panel Vector Error Correction (PVECM), which involves variance decomposition. The results show that foreign direct investment (FDI) positively and significantly affects employment. Other variables that show a significant relationship with employment are wage rate, education expenditure, and interest rate. The variance decomposition result revealed that external shocks on remittances and FDI have short- and long-term effects on employment. The above findings imply that foreign direct investment has a far-reaching positive impact on the economy-wide management of the West African sub-region and thus calls for relevant policy options. Full article

(This article belongs to the Special Issue Macroeconomic Dynamics and Economic Growth)

22 pages, 2670 KiB

Open AccessReview

Sodium Chloride in Food

by Sylwia Chudy, Agnieszka Makowska and Ryszard Kowalski

Foods 2025, 14(15), 2741; https://doi.org/10.3390/foods14152741 (registering DOI) - 6 Aug 2025

Abstract

Sodium chloride is a chemical compound that has been encountered by people for thousands of years, and plays a significant role in their lives. The aim of this article is to provide a comprehensive review of table salt from the perspective of health, [...] Read more.

Sodium chloride is a chemical compound that has been encountered by people for thousands of years, and plays a significant role in their lives. The aim of this article is to provide a comprehensive review of table salt from the perspective of health, food technology, and cultural heritage. The article discusses salt extraction and production, its composition and consumption, and its effects on the human body. The authors draw attention to new trends, such as the use of micronized salt, microencapsulated salt, and salt with colors and shapes that differ from those of typical table salt. Scientific studies on the presence of undesirable substances and the use of salt additives were reviewed. The role of salt in dairy, meat, and bakery technology was illustrated. Gaps in research on salt were highlighted. In the last part, all types of salt with geographical indications are shown. The paper suggests that producers with a long tradition in the salt sector should apply for the European geographical indications to enhance their national and cultural heritage and promote their region. The review highlights the need for further research on all aspects discussed. Full article

(This article belongs to the Section Food Quality and Safety)

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22 pages, 518 KiB

Open AccessArticle

Staying or Leaving a Shrinking City: Migration Intentions of Creative Youth in Erzurum, Eastern Türkiye

by Defne Dursun and Doğan Dursun

Sustainability 2025, 17(15), 7109; https://doi.org/10.3390/su17157109 (registering DOI) - 6 Aug 2025

Abstract

This study explores the migration intentions of university students—representing the potential creative class—in Erzurum, a medium-sized city in eastern Turkey experiencing shrinkage. Within the theoretical framework of shrinking cities, it investigates how economic, social, physical, and personal factors influence students’ post-graduation stay or [...] Read more.

This study explores the migration intentions of university students—representing the potential creative class—in Erzurum, a medium-sized city in eastern Turkey experiencing shrinkage. Within the theoretical framework of shrinking cities, it investigates how economic, social, physical, and personal factors influence students’ post-graduation stay or leave decisions. Survey data from 742 Architecture and Fine Arts students at Atatürk University were analyzed using factor analysis, logistic regression, and correlation to identify key migration drivers. Findings reveal that, in addition to economic concerns such as limited job opportunities and low income, personal development opportunities and social engagement also play a decisive role. In particular, the perception of limited chances for skill enhancement and the belief that Erzurum is not a good place to meet people emerged as the strongest predictors of migration intentions. These results suggest that members of the creative class are influenced not only by economic incentives but also by broader urban experiences related to self-growth and social connectivity. This study highlights spatial inequalities in access to cultural, educational, and social infrastructure, raising important questions about spatial justice in shrinking urban contexts. This paper contributes to the literature on shrinking cities by highlighting creative youth in mid-sized Global South cities. It suggests smart shrinkage strategies focused on creative sector development, improved quality of life, and inclusive planning to retain young talent and support sustainable urban revitalization. Full article

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19 pages, 541 KiB

Open AccessArticle

Export-Led Growth Under the Digital Economy: Evidence from China’s 31 Provinces

by Xiaomei Li, Radziah Adam and Ningjun Deng

Sustainability 2025, 17(15), 7111; https://doi.org/10.3390/su17157111 (registering DOI) - 6 Aug 2025

Abstract

Under the rapid development of the digital economy, the interactive relationship between exports and the digital economy has become an important issue for promoting regional economic growth. Based on the panel data of 31 provinces and municipalities in China from 2012 to 2022, [...] Read more.

Under the rapid development of the digital economy, the interactive relationship between exports and the digital economy has become an important issue for promoting regional economic growth. Based on the panel data of 31 provinces and municipalities in China from 2012 to 2022, this paper systematically examines the impact of exports on economic growth and the moderating role of the digital economy, and it introduces research and development (R&D) investment to test its mediating mechanism. The research finds that exports significantly promote regional economic growth. The digital economy has a negative moderating effect on the export growth effect, and it is significant in the eastern region but not significant in the central and western regions, showing obvious regional heterogeneity. R&D investment has played a partial mediating role between exports and economic growth. This paper suggests that the government should focus on regional differences, promote the deep integration of the digital economy and exports, enhance technological innovation capabilities, formulate differentiated policies based on local conditions, strengthen the construction of digital infrastructure, optimize the export structure, support the development of R&D-driven enterprises, and build a digital export system that promotes regional coordination and high-quality growth, so as to achieve high-quality coordinated sustainable regional development. This paper also has certain reference value for other developing economies, in promoting the integration of the digital economy and trade. Full article

(This article belongs to the Special Issue Digital Transformation and Economic Development: Strategies for Sustainable Industrial Competitiveness)

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18 pages, 404 KiB

Open AccessArticle

Deterministic Scheduling for Asymmetric Flows in Future Wireless Networks

by Haie Dou, Taojie Zhu, Fei Li, Chen Liu and Lei Wang

Symmetry 2025, 17(8), 1246; https://doi.org/10.3390/sym17081246 (registering DOI) - 6 Aug 2025

Abstract

In the era of Industry 5.0, future wireless networks are increasingly shifting from traditional symmetric architectures toward heterogeneous and asymmetric paradigms, driven by the demand for diversified and dynamic services. This architectural evolution gives rise to complex and asymmetric flows, such as the [...] Read more.

In the era of Industry 5.0, future wireless networks are increasingly shifting from traditional symmetric architectures toward heterogeneous and asymmetric paradigms, driven by the demand for diversified and dynamic services. This architectural evolution gives rise to complex and asymmetric flows, such as the coexistence of periodic and burst flows with varying latency, jitter, and deadline constraints, posing new challenges for deterministic transmission. Traditional time-sensitive networking (TSN) is well-suited for periodic flows but lacks the flexibility to effectively handle dynamic, asymmetric traffi. To address this limitation, we propose a two-stage asymmetric flow scheduling framework with dynamic deadline control, termed A-TSN. In the first stage, we design a Deep Q-Network-based Dynamic Injection Time Slot algorithm (DQN-DITS) to optimize slot allocation for periodic flows under varying network loads. In the second stage, we introduce the Dynamic Deadline Online (DDO) scheduling algorithm, which enables real-time scheduling for asymmetric flows while satisfying flow deadlines and capacity constraints. Simulation results demonstrate that our approach significantly reduces end-to-end latency, improves scheduling efficiency, and enhances adaptability to high-volume asymmetric traffic, offering a scalable solution for future deterministic wireless networks. Full article

(This article belongs to the Special Issue Symmetry/Asymmetry in Future Wireless Networks)

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19 pages, 2638 KiB

Open AccessArticle

Population Viability Analysis of the Federally Endangered Endemic Jacquemontia reclinata (Convolvulaceae): A Comparative Analysis of Average vs. Individual Matrix Dynamics

by John B. Pascarella

Conservation 2025, 5(3), 40; https://doi.org/10.3390/conservation5030040 (registering DOI) - 6 Aug 2025

Abstract

Due to small population size, Population Viability Analysis (PVA) of endangered species often pools all individuals into a single matrix to decrease variation in estimation of transition rates. These pooled populations may mask significant environmental variation among populations, affecting estimates. Using 10 years [...] Read more.

Due to small population size, Population Viability Analysis (PVA) of endangered species often pools all individuals into a single matrix to decrease variation in estimation of transition rates. These pooled populations may mask significant environmental variation among populations, affecting estimates. Using 10 years of population data (2000–2010) on the endangered plant Jacquemontia reclinata in Southeastern Florida, USA, I parameterized a stage-structured matrix model and calculated annual growth rates (lambdas)and elasticity for each year using stochastic matrix models. The metapopulation model incorporating actual dynamics of the two largest populations showed a lower occupancy rate and higher risk of extinction at an earlier time compared to a model that used the average of all natural populations. Analyses were consistent that incorporating population variation versus average dynamics in modeling J. reclinata demography results in more variation and greater extinction risk. Local variation may be due to both weather (including minimum winter temperature and total annual precipitation) and local disturbance dynamics in these urban preserves. Full article

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