Enzymes and Enzyme Inhibitors in Drug Research

Dear Colleagues,

Enzymes are involved in many pathological conditions, such as inflammation, diabetes, microbial infections, HIV, neoplastic diseases and others. Enzyme inhibition is universally accepted as a strategy to treat the above-mentioned conditions or to reverse the mechanism involved. In the long drug development process, the design of potent enzyme inhibitors is a crucial step. This Topic is dedicated to enzymes and their inhibition in drug design and development; these may include HIV-1 RT, transcriptase, SAR CoV-2, PTP1B, LOX, COX carbonic anhydrase, aldose reductase, and many others.

We welcome relevant original research, reviews, and other articles that cover (but are not limited to) the following subjects:

• The role of enzymes in many pathological conditions;
• Strategies for the development of enzyme inhibitors;
• Targets for the development of new drugs, as well as the role of computational chemistry in drug design.

Prof. Dr. Athina Geronikaki
Prof. Dr. Cosimo D. Altomare
Prof. Dr. Maria Stefania Sinicropi
Topic Editors